EVALUATION OF EUDRAGIT RS AND RL SOLID DISPERSION SYSTEMS IN PREPARATION OF DICLOFENAC SODIUM SUSTAINED RELEASE MATRICES

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SADEGHI FATEMEH; AFRASIABI GAREKANI H.; HAJI AGHAPOUR N.

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Journal: PHARMACEUTICAL SCIENCES Year:2003 | Volume:- | Issue:2 Page(s): 49-62

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Title

EVALUATION OF EUDRAGIT RS AND RL SOLID DISPERSION SYSTEMS IN PREPARATION OF DICLOFENAC SODIUM SUSTAINED RELEASE MATRICES

Author(s)

SADEGHI FATEMEH | AFRASIABI GAREKANI H. | HAJI AGHAPOUR N. | Issue Writer Certificate

Keywords

SUSTAINED RELEASEQ2

MATRIXQ2

SOLID DISPERSIONQ3

EUDRAGITQ3

Abstract

Eudragits are synthetic copolymers of acrylate that have been known as suitable carriers for preparation of SUSTAINED RELEASE matrices. SOLID DISPERSION (SD) systems which at first had been used to enhance the dissolution rate of poorly water soluble drugs is now widely used in preparation of SUSTAINED RELEASE matrices. This study was performed in order to evaluate the EUDRAGIT RL and RS SOLID DISPERSION systems in preparation of SUSTAINED RELEASE diclofenac sodium matrices. The effect of drug and polymer mixture preparation and drug polymer ratio on the properties of matrices such as its crushing strength, drug release rate and mechanism were studied. The results showed that increasing the polymer content increased the cl1lshing strength of matrices prepared either from physical mixture or SD system and decreased the rate of drug released. Matrices prepared from SD system were harder than those prepared from physical mixtures and the rate of drug release from former matrices was considerably slower than the latter matrices. Comparison of drug release at the same drug: polymer ratio showed that drug release rate from E.RL matrices was slower than E.RS matrices except in matrices prepared from physical mixture with I: 1 drug: polymer ratio. This was attributed to the electrostatic interaction between polymers and drug. The electrostatic interaction between drug and polymers was confirmed by measuring the amount of drug absorbed on the polymers in the presence of Tween 80 or SLS. As E.RL contains more ammonium groups than E.RS therefore the extent of interaction between dic10fenac sodium and E.RL could be greater than E.RS. This could explain the slower drug release rate from E.RL matrices compared to E.RS. In SD systems the extent of interaction between drug and polymers increased and this retarded the rate of drug released. It was shown that in the most cases diffusion was the main mechanism controlling drug release rate. In conclusion the use of SOLID DISPERSION systems is valuble in production of SUSTAINED RELEASE matrices of E.RL and E.RS and can lead to less polymer consumption compared to physical mixtures of drug and polymer in order to control drug release rate. These systems due to very slow rate of drug release are also useful in production of transdermal drug delivery systems.

Cites

PREPARATION AND EVALUATION OF MICROCAPSULES CONTAINING DICLOFENAC SODIUM AND EUDRAGIT RS OR RL AS ORAL SUSTAINED RELEASE MULTIPARTICULTE DELIVERY SYSTEM

References

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APA: Copy

SADEGHI, FATEMEH, AFRASIABI GAREKANI, H., & HAJI AGHAPOUR, N.. (2003). EVALUATION OF EUDRAGIT RS AND RL SOLID DISPERSION SYSTEMS IN PREPARATION OF DICLOFENAC SODIUM SUSTAINED RELEASE MATRICES. PHARMACEUTICAL SCIENCES, -(2), 49-62. SID. https://sid.ir/paper/48648/en

Vancouver: Copy

SADEGHI FATEMEH, AFRASIABI GAREKANI H., HAJI AGHAPOUR N.. EVALUATION OF EUDRAGIT RS AND RL SOLID DISPERSION SYSTEMS IN PREPARATION OF DICLOFENAC SODIUM SUSTAINED RELEASE MATRICES. PHARMACEUTICAL SCIENCES[Internet]. 2003;-(2):49-62. Available from: https://sid.ir/paper/48648/en

IEEE: Copy

FATEMEH SADEGHI, H. AFRASIABI GAREKANI, and N. HAJI AGHAPOUR, “EVALUATION OF EUDRAGIT RS AND RL SOLID DISPERSION SYSTEMS IN PREPARATION OF DICLOFENAC SODIUM SUSTAINED RELEASE MATRICES,” PHARMACEUTICAL SCIENCES, vol. -, no. 2, pp. 49–62, 2003, [Online]. Available: https://sid.ir/paper/48648/en

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