STUDY OF DRUG RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS STRAINS ISOLATED FROM PULMONARY TUBERCULOSIS PATIENTS

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MOADAB SEYED REZA; RAFI A.

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Journal: PHARMACEUTICAL SCIENCES Year:2003 | Volume:- | Issue:2 Page(s): 91-100

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Title

STUDY OF DRUG RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS STRAINS ISOLATED FROM PULMONARY TUBERCULOSIS PATIENTS

Author(s)

MOADAB SEYED REZA | RAFI A. | Issue Writer Certificate

Keywords

DRUG-RESISTANCEQ2

PRIMARY-RESISTANCEQ3

SECONDARY-RESISTANCEQ3

MYCOBACTERIUM TUBERCULOSISQ2

ISTANBULQ3

Abstract

Drug-resistant tuberculosis is an increasing health problem and serious challenge to TB control programmes. The objective of this study was to detect the frequency of drug - resistant among patients with pulmonary tuberculosis in ISTANBUL, Turkey and to compare with other studies performed in Iran and some other countries. Ninety-one MYCOBACTERIUM TUBERCULOSIS strains were isolated from the same number of patients at Cerrahpasa Medical Faculty Hospital of ISTANBUL, Turkey. Sputum samples were cultured on Lowenstain-Jensen medium by standard method. All strains were tested against isoniazid (INH), rifampin (RMP), ethambutol (EMB) and streptomycin (SM) using the proportion method on Lowenstein-Jensen medium. The overall resistance rate was 44%. Primary resistance to SM was the most frequent (21.1%) followed by INH (15.8%), RMP (5.3%) and EMB (2.6%) respectively. Primary multidrug resistance (MDR) was (2.6%). Secondary resistance was the most frequent to INH (33.3%) followed by SM (28.6%), RMP (23.8%) and EMB (14.3%) respectively. Secondary MDR found to be 11.9%. Our results were compared with some other studies in Iran and other countries. Due to high prevalence of drug resistance particularly in developing countries, further studies should be conducted regularly to monitor drug resistance in these countries.

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بررسی نوع مایکوباکتریوم و تعیین حساسیت دارویی مایکوباکتریوم توبر کولوزیس جدا شده از نمونه های کلینیکی در کاشان

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APA: Copy

MOADAB, SEYED REZA, & RAFI, A.. (2003). STUDY OF DRUG RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS STRAINS ISOLATED FROM PULMONARY TUBERCULOSIS PATIENTS. PHARMACEUTICAL SCIENCES, -(2), 91-100. SID. https://sid.ir/paper/48651/en

Vancouver: Copy

MOADAB SEYED REZA, RAFI A.. STUDY OF DRUG RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS STRAINS ISOLATED FROM PULMONARY TUBERCULOSIS PATIENTS. PHARMACEUTICAL SCIENCES[Internet]. 2003;-(2):91-100. Available from: https://sid.ir/paper/48651/en

IEEE: Copy

SEYED REZA MOADAB, and A. RAFI, “STUDY OF DRUG RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS STRAINS ISOLATED FROM PULMONARY TUBERCULOSIS PATIENTS,” PHARMACEUTICAL SCIENCES, vol. -, no. 2, pp. 91–100, 2003, [Online]. Available: https://sid.ir/paper/48651/en

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