EFFECTS OF HALOTHANE ON LEARNING AND MEMORY CONSOLIDATION ON MALE RATS

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BABRI SH.; KHAMENEH SAEID; MOTAMEDI F.

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Journal: PHARMACEUTICAL SCIENCES Year:2003 | Volume:- | Issue:2 Page(s): 1-8

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Title

EFFECTS OF HALOTHANE ON LEARNING AND MEMORY CONSOLIDATION ON MALE RATS

Author(s)

BABRI SH. | KHAMENEH SAEID | MOTAMEDI F. | Issue Writer Certificate

Keywords

MEMORYQ3

HALOTHANEQ3

PASSIVE AVOIDANCEQ2

AMNESIAQ3

Abstract

Inhaling anesthetics constitute a group of important pharmacological agents used in clinic. HALOTHANE is one of these agents, that there is ambiguity about its effect on MEMORY. In the present study 7 group of rats (10 rats per group) from A to G were incorporated. Group A were trained in PASSIVE AVOIDANCE box (one trial) and then were tested 24 hours later. Group B and C were anesthetized by HALOTHANE (3%) for 15 and 60 min respectively immediately after they have been trained. Group D and E were anesthetized for a similar periods but before training. Group F were trained several times (multi trial) until the rats learned, so that they didn't enter the dark room. Group G were treated as group F but went under HALOTHANE anesthesia for 15 min before training. MEMORY retrieval was tested in all groups 24 hours after training. HALOTHANE anesthesia immediately following training had no significant effect on MEMORY consolidation. Despite the fact that pretraining exposure to HALOTHANE did not interfere with learning, but significantly affected MEMORY (p<0.05). These results suggest that posttrai1ing HALOTHANE anesthesia has no effect on MEMORY consolidation and its retrieval, while pertaining HALOTHANE anesthesia severely affects both of these

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APA: Copy

BABRI, SH., KHAMENEH, SAEID, & MOTAMEDI, F.. (2003). EFFECTS OF HALOTHANE ON LEARNING AND MEMORY CONSOLIDATION ON MALE RATS. PHARMACEUTICAL SCIENCES, -(2), 1-8. SID. https://sid.ir/paper/48655/en

Vancouver: Copy

BABRI SH., KHAMENEH SAEID, MOTAMEDI F.. EFFECTS OF HALOTHANE ON LEARNING AND MEMORY CONSOLIDATION ON MALE RATS. PHARMACEUTICAL SCIENCES[Internet]. 2003;-(2):1-8. Available from: https://sid.ir/paper/48655/en

IEEE: Copy

SH. BABRI, SAEID KHAMENEH, and F. MOTAMEDI, “EFFECTS OF HALOTHANE ON LEARNING AND MEMORY CONSOLIDATION ON MALE RATS,” PHARMACEUTICAL SCIENCES, vol. -, no. 2, pp. 1–8, 2003, [Online]. Available: https://sid.ir/paper/48655/en

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