STUDY OF ISCHEMIC AND PHARMACOLOGIC POSTCONDITIONING ON INFARCT SIZE IN THE ISCHEMIC REPERFUSED ISOLATED HEART

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NAJAFI M.; GARJANI A.; ETERAF OSKOUEI T.

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Journal: PHARMACEUTICAL SCIENCES Year:2007 | Volume:- | Issue:1 Page(s): 23-28

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Title

STUDY OF ISCHEMIC AND PHARMACOLOGIC POSTCONDITIONING ON INFARCT SIZE IN THE ISCHEMIC REPERFUSED ISOLATED HEART

Author(s)

NAJAFI M. | GARJANI A. | ETERAF OSKOUEI T. | Issue Writer Certificate

Keywords

POSTCONDITIONINGQ2

L- CARNITINEQ2

ISCHEMIA- REPERFUSIONQ2

INFARCT SIZEQ2

ISOLATED HEARTQ2

Abstract

Objectives: In this study, effects of ischemic POSTCONDITIONING (IPC) and pharmacologic POSTCONDITIONING (PPC) by using L-Carnitine (L- Car) on INFARCT SIZE in the ischemic-reperfused isolated rat heart were investigated and compared. Methods: Male rats were divided in five groups (control, IPC, and three PPC groups treated by L- Car) and were anesthetized by sodium pentobarbital (50 mg/kg-ip). Heart was removed and quickly mounted on a Langendorff apparatus and perfused by a modified Krebs- Henseleit (K/H) solution that was previously equilibrated with 95% O2–5% CO2. The hearts were subjected to 30 min regional ischemia followed by 120 min reperfusion. In the control and IPC groups, the hearts were perfused by normal K/H solution at stabilization, 30 min regional ischemia and 120 min reperfusion, while PPC groups were perfused by 0.5, 2.5 and 5mM of L-Car enriched K/H solution 10 min before and after reperfusion. At the end of reperfusion, INFARCT SIZE was determined by triphenyltetrazolium chloride method and computerized planimetry. Results: INFARCT SIZE was decreased significantly in both IPC and PPC groups versus control. In control group, INFARCT SIZE was 46.3±2.9 %, however, IPC reduced it to 22.6±1.5 % (p<0.001). Application of 0.5, 2, 5 and 5mM of Car-enriched K/H solution 10 min before and after reperfusion in the PPC groups, reduced the INFARCT SIZE from control group value to 41.8±4.0 (not significant), 28.1±2.0 (p<0.001) and 25.4±3.9 % (p<0.001), respectively. Except the effects of 0.5 mM L- Car, there was no significant difference between IPC and PPC groups on INFARCT SIZE reduction. Conclusion: Considering the results, it may be concluded that IPC and PPC (by L- Car) have protective effects against cardiac I/R injuries by reduction of INFARCT SIZE.

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References

STUDY THE EFFECT OF L-CARNITINE ON INFARCT SIZE IN THE ISCHEMIC–REPERFUSED ISOLATED RAT HEARTS

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APA: Copy

NAJAFI, M., GARJANI, A., & ETERAF OSKOUEI, T.. (2007). STUDY OF ISCHEMIC AND PHARMACOLOGIC POSTCONDITIONING ON INFARCT SIZE IN THE ISCHEMIC REPERFUSED ISOLATED HEART. PHARMACEUTICAL SCIENCES, -(1), 23-28. SID. https://sid.ir/paper/48658/en

Vancouver: Copy

NAJAFI M., GARJANI A., ETERAF OSKOUEI T.. STUDY OF ISCHEMIC AND PHARMACOLOGIC POSTCONDITIONING ON INFARCT SIZE IN THE ISCHEMIC REPERFUSED ISOLATED HEART. PHARMACEUTICAL SCIENCES[Internet]. 2007;-(1):23-28. Available from: https://sid.ir/paper/48658/en

IEEE: Copy

M. NAJAFI, A. GARJANI, and T. ETERAF OSKOUEI, “STUDY OF ISCHEMIC AND PHARMACOLOGIC POSTCONDITIONING ON INFARCT SIZE IN THE ISCHEMIC REPERFUSED ISOLATED HEART,” PHARMACEUTICAL SCIENCES, vol. -, no. 1, pp. 23–28, 2007, [Online]. Available: https://sid.ir/paper/48658/en

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