THE EFFECT OF QUERCETIN (FROM ONION) AND ACTH ON MORPHINE INDUCED TOLERANCE AND DEPENDENCE IN MICE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HABIBIASL B.; ASADI M.; SABZEVARI A.; BABRI J.; DELAZAR A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: PHARMACEUTICAL SCIENCES Year:2007 | Volume:- | Issue:1 Page(s): 1-9

Download Full-Text

Persian Verion

View:

891

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF QUERCETIN (FROM ONION) AND ACTH ON MORPHINE INDUCED TOLERANCE AND DEPENDENCE IN MICE

Author(s)

Keywords

ACTHQ2

QUERCETINQ2

MORPHINEQ2

TOLERANCEQ2

WITHDRAWALQ2

Abstract

Objectives: The goal of this study was to evaluate the effects of ACTH and QUERCETIN on preventing the development of MORPHINE TOLERANCE and dependence in mice.Methods: In this study different groups of mice (20-30 g) received MORPHINE (40 mg/kg, ip), MORPHINE (40 mg/kg, ip) + ACTH (1,2.5,5 IU/mice, ip), MORPHINE (40 mg/kg, ip) + QUERCETIN (5,10,25 mg/kg, ip), MORPHINE (40 mg/kg, ip) + QUERCETIN (5mg/kg, ip)+ ACTH (1 IU/mice, ip)] once a day for four days. TOLERANCE was assessed by administration of MORPHINE (9 mg/kg, ip) and using hot plate test on fifth day. WITHDRAWAL symptoms were assessed by administration of naloxone (4 mg/kg, ip) two hours after co-administration of MORPHINE with either QUERCETIN or ACTH. Results: It was found that pretreatment with QUERCETIN or ACTH decreased the degree of TOLERANCE and dependence significantly. Additionally, coadministration of QUERCETIN and ACTH before MORPHINE administration decreased significantly the TOLERANCE and dependency. From these results it may be concluded that administration of QUERCETIN or ACTH injection alone or in together could affect the decrease WITHDRAWAL signs and TOLERANCE of MORPHINE. These effects may be related to as nitric oxide inhibitor (NOI) behavior of QUERCETIN and the ability of MORPHINE and their receptors in the control of the secretion of CRH. Conclusion: ACTH, QUERCETIN and co-administration of both drugs significantly inhibited the development of MORPHINE induced TOLERANCE and dependence in mice.

Cites

No record.

References

No record.

Cite

APA: Copy

HABIBIASL, B., ASADI, M., SABZEVARI, A., BABRI, J., & DELAZAR, A.. (2007). THE EFFECT OF QUERCETIN (FROM ONION) AND ACTH ON MORPHINE INDUCED TOLERANCE AND DEPENDENCE IN MICE. PHARMACEUTICAL SCIENCES, -(1), 1-9. SID. https://sid.ir/paper/48663/en

Vancouver: Copy

HABIBIASL B., ASADI M., SABZEVARI A., BABRI J., DELAZAR A.. THE EFFECT OF QUERCETIN (FROM ONION) AND ACTH ON MORPHINE INDUCED TOLERANCE AND DEPENDENCE IN MICE. PHARMACEUTICAL SCIENCES[Internet]. 2007;-(1):1-9. Available from: https://sid.ir/paper/48663/en

IEEE: Copy

B. HABIBIASL, M. ASADI, A. SABZEVARI, J. BABRI, and A. DELAZAR, “THE EFFECT OF QUERCETIN (FROM ONION) AND ACTH ON MORPHINE INDUCED TOLERANCE AND DEPENDENCE IN MICE,” PHARMACEUTICAL SCIENCES, vol. -, no. 1, pp. 1–9, 2007, [Online]. Available: https://sid.ir/paper/48663/en

Related Journal Papers