EVALUATION OF ENHANCED DISSOLUTION RATE OF INDOMETHACIN USING LIQUISOLID TECHNIQUE

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JAVADZADEH Y.; NOKHOUDCHI A.; BAFANDEH A.; SIAHI M.R.; ASNAASHARI S.

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Journal: PHARMACEUTICAL SCIENCES Year:2005 | Volume:- | Issue:2 Page(s): 45-53

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Title

EVALUATION OF ENHANCED DISSOLUTION RATE OF INDOMETHACIN USING LIQUISOLID TECHNIQUE

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Keywords

INDOMETHACINQ2

DISSOLUTION RATEQ2

LIQUISOLIDQ2

Abstract

OBJECTIVES: For poorly soluble, highly permeable (Class II) drugs, such as INDOMETHACIN, the rate of GI absorption is often controlled by the DISSOLUTION RATE in the gastrointestinal tract. There are several techniques to enhance the dissolution of poorly soluble substances. Among them, the technique of LIQUISOLID compact is a promising technique to increase DISSOLUTION RATE of poorly soluble drugs. The aim of this study was to asses the use of LIQUISOLID technique in enhancing DISSOLUTION RATE of INDOMETHACIN and evaluation of effect of various carriers and solvents on drug release from its LIQUISOLID 'tablets. METHODS: In this study, the dissolution behaviors of INDOMETHACIN from LIQUISOLID compacts were investigated at two different media Simulated Gastric Fluid (SGF, pH=1.2) and Simulated Intestinal Fluid (SIF, pH=7.2). To this end, several formulations of LIQUISOLID compacts containing variety of carriers (microcrystalline cellulose, lactose, starch, sorbitol and manitol) and nonvolatile solvents in various ratios of drug: solvent (polyethylene glycol 400) were prepared and dissolution profile of them were studied, Results: The results showed that LIQUISOLID compacts demonstrated a considerably higher drug DISSOLUTION RATEs than those of conventionally made capsules and directly compressed tablets. This was due to the increased wetting properties and surface of drug available for dissolution. The results showed that the DISSOLUTION RATE of the drug in SIF is better than SGF medium. In the evaluation of the kind of solvents, there were not any significant differences between solvents in SIF medium but in SGF, the formulation containing propylene glycol as solvent had a better dissolution profile. Among the carriers, also microcrystalline cellulose had better liquid retention potential, but in both SGF and SIF media, there was no significant difference between the DISSOLUTION RATEs of formulations. CONCLUSION: It can be concluded that the LIQUISOLID technique can be used to increase the DISSOLUTION RATE of poorly water soluble drugs.

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APA: Copy

JAVADZADEH, Y., NOKHOUDCHI, A., BAFANDEH, A., SIAHI, M.R., & ASNAASHARI, S.. (2005). EVALUATION OF ENHANCED DISSOLUTION RATE OF INDOMETHACIN USING LIQUISOLID TECHNIQUE. PHARMACEUTICAL SCIENCES, -(2), 45-53. SID. https://sid.ir/paper/48713/en

Vancouver: Copy

JAVADZADEH Y., NOKHOUDCHI A., BAFANDEH A., SIAHI M.R., ASNAASHARI S.. EVALUATION OF ENHANCED DISSOLUTION RATE OF INDOMETHACIN USING LIQUISOLID TECHNIQUE. PHARMACEUTICAL SCIENCES[Internet]. 2005;-(2):45-53. Available from: https://sid.ir/paper/48713/en

IEEE: Copy

Y. JAVADZADEH, A. NOKHOUDCHI, A. BAFANDEH, M.R. SIAHI, and S. ASNAASHARI, “EVALUATION OF ENHANCED DISSOLUTION RATE OF INDOMETHACIN USING LIQUISOLID TECHNIQUE,” PHARMACEUTICAL SCIENCES, vol. -, no. 2, pp. 45–53, 2005, [Online]. Available: https://sid.ir/paper/48713/en

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