STUDY OF THE EFFECT OF FLAVOR TYPE ON THE VOLUNTEERS' ACCEPTANCE OF ACETAMINOPHEN SYRUP PREPARED BY THREE DOMESTIC FACTORIES

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ZARINTAN M.H.; SATAR ZADEH A.S.

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Journal: PHARMACEUTICAL SCIENCES Year:2005 | Volume:- | Issue:2 Page(s): 41-44

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Title

STUDY OF THE EFFECT OF FLAVOR TYPE ON THE VOLUNTEERS' ACCEPTANCE OF ACETAMINOPHEN SYRUP PREPARED BY THREE DOMESTIC FACTORIES

Author(s)

ZARINTAN M.H. | SATAR ZADEH A.S. | Issue Writer Certificate

Keywords

FLAVORED SYRUPSQ2

TASTE AND FLAVORQ2

ACETAMINOPHENQ2

Abstract

OBJECTIVES: Improvement on the taste of liquid dosage forms has always been important in respect to the acceptance of patient. Many methods including the addition of flavoring agents can solve the problem of the unpatability of dosage forms making them acceptable to the patients, the objective which was followed at the present study. METHODS: The patability and acceptance of ACETAMINOPHEN syrups prepared by three domestic factories using different flavoring agents (I, I, III) were evaluated in 50 healthy adult males and females in the age ranges of 20-25 years old. The tested samples were 120 mg 15ml ACETAMINOPHEN syrups flavored by orange oil and raspoeny extract. RESULTS: Generally recommended procedures for taste test were followed and the results showed taste preference\for one of the factories (I), which had used raspbeny extract as flavoring agent. The significance of the results was checked with chi-square statistical analysis and type one error (a= 0.05). It may be needed to mention that the preferred flavor by volunteers was accorded with what B.P. used in this pharmacopoeia for flavoring ACETAMINOPHEN liquid dosage form, which confirms the results of this study. CONCLUSION: The findings of the study showed that the acceptance for ACETAMINOPHEN syrup flavored with raspbeny extract was better compared to those of flavored with orange oil. The raspbeny extract did not allow ACETAMINOPHEN to have contact with taste buds on the tongue and the patients accepted dosage form made with this flavor. Taste improvement of oral liquid dosage forms with orange oil needs enough concentration of this flavor.

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APA: Copy

ZARINTAN, M.H., & SATAR ZADEH, A.S.. (2005). STUDY OF THE EFFECT OF FLAVOR TYPE ON THE VOLUNTEERS' ACCEPTANCE OF ACETAMINOPHEN SYRUP PREPARED BY THREE DOMESTIC FACTORIES. PHARMACEUTICAL SCIENCES, -(2), 41-44. SID. https://sid.ir/paper/48718/en

Vancouver: Copy

ZARINTAN M.H., SATAR ZADEH A.S.. STUDY OF THE EFFECT OF FLAVOR TYPE ON THE VOLUNTEERS' ACCEPTANCE OF ACETAMINOPHEN SYRUP PREPARED BY THREE DOMESTIC FACTORIES. PHARMACEUTICAL SCIENCES[Internet]. 2005;-(2):41-44. Available from: https://sid.ir/paper/48718/en

IEEE: Copy

M.H. ZARINTAN, and A.S. SATAR ZADEH, “STUDY OF THE EFFECT OF FLAVOR TYPE ON THE VOLUNTEERS' ACCEPTANCE OF ACETAMINOPHEN SYRUP PREPARED BY THREE DOMESTIC FACTORIES,” PHARMACEUTICAL SCIENCES, vol. -, no. 2, pp. 41–44, 2005, [Online]. Available: https://sid.ir/paper/48718/en

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