ANTINOCICEPTIVE EFFECT OF ASCORBIC ACID AND INVOLVEMENT OF NITRIC OXIDE IN A CHRONIC PAIN MODEL

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NASIRINEZHAD F.; SAFARPOUR S.

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Journal: PHARMACEUTICAL SCIENCES Year:2010 | Volume:16 | Issue:3 Page(s): 157-168

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Title

ANTINOCICEPTIVE EFFECT OF ASCORBIC ACID AND INVOLVEMENT OF NITRIC OXIDE IN A CHRONIC PAIN MODEL

Author(s)

NASIRINEZHAD F. | SAFARPOUR S. | Issue Writer Certificate

Keywords

ASCORBIC ACIDQ1

NITRIC OXIDEQ1

NEUROPATHIC PAINQ1

Abstract

Objectives: Ascorbate which is presented in high concentration in nervous system, inhibit NITRIC OXIDE synthase enzyme (NOS). We investigated the involvement of NO pathway in the analgesic effects of ASCORBIC ACID (AA) in CCI model of neuropathic rats.Methods: In this experimental study, NEUROPATHIC PAIN is induced by 4 loose ligature around sciatic nerve on left paw of male rats using 4.0 chromic gut (CCI model). ASCORBIC ACID (1, 5 or 10 mg/kg) or saline was injected intraperituneally two weeks after CCI. Heat and mechanical hyperalgesia and mechanical allodynia were investigated 15 and 30 min after injection. To investigate the involvement of NO on antinociceptive effect of AA on the second week after CCI, 30 min after injection of saline or AA, animals received intraperitunealy injection of L-arginin (500 mg/kg), or L-NAME (20mg/kg) and were tested 20 min after on.Results: Acute injection of 5 and 10 mg/kg but not 1 mg/kg of AA increased pain threshold in the second week after CCI. Injection of 5 mg/kg AA inhibited the nociceptive effect of L-arginin and potentiates the antinociceptive effect of L-NAME and pain threshold was significantly different in these two groups comparing the animals which received normal saline instead of AA.Conclusion: Injection of AA increase pain threshold after nerve injury. Antinociceptive effect of ASCORBIC ACID is dose dependant and that seems to be mediated at least partially via NO pathway.

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APA: Copy

NASIRINEZHAD, F., & SAFARPOUR, S.. (2010). ANTINOCICEPTIVE EFFECT OF ASCORBIC ACID AND INVOLVEMENT OF NITRIC OXIDE IN A CHRONIC PAIN MODEL. PHARMACEUTICAL SCIENCES, 16(3), 157-168. SID. https://sid.ir/paper/48730/en

Vancouver: Copy

NASIRINEZHAD F., SAFARPOUR S.. ANTINOCICEPTIVE EFFECT OF ASCORBIC ACID AND INVOLVEMENT OF NITRIC OXIDE IN A CHRONIC PAIN MODEL. PHARMACEUTICAL SCIENCES[Internet]. 2010;16(3):157-168. Available from: https://sid.ir/paper/48730/en

IEEE: Copy

F. NASIRINEZHAD, and S. SAFARPOUR, “ANTINOCICEPTIVE EFFECT OF ASCORBIC ACID AND INVOLVEMENT OF NITRIC OXIDE IN A CHRONIC PAIN MODEL,” PHARMACEUTICAL SCIENCES, vol. 16, no. 3, pp. 157–168, 2010, [Online]. Available: https://sid.ir/paper/48730/en

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