COMPARING THE EFFECTS OF FLUOXETINE AND ALPRAZOLAM ON BLOOD GLUCOSE IN PATIENTS WITH TYPE 2 DIABETES

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AFKHAMI ARDEKANI MOHAMMAD; SHOJA ALDINI ARDAKANI A.; SOLTANI V.; MOLA NOURI E.

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Journal: Journal of Inflammatory Diseases Year:2008 | Volume:12 | Issue:1 (46) Page(s): 21-26

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Title

COMPARING THE EFFECTS OF FLUOXETINE AND ALPRAZOLAM ON BLOOD GLUCOSE IN PATIENTS WITH TYPE 2 DIABETES

Author(s)

AFKHAMI ARDEKANI MOHAMMAD | SHOJA ALDINI ARDAKANI A. | SOLTANI V. | MOLA NOURI E. | Issue Writer Certificate

Keywords

FLUOXETINEQ3

ALPRAZOLAMQ2

BLOOD GLUCOSEQ3

TYPE2 DIABETES MELLITUSQ2

Abstract

Background: Diabetes mellitus is the most common endocrine disorder causing micro- and macrovascular complications which could be prevented by good glycemic control. Considering many patients who become resistant to routine anti-diabetic drugs after few years, the administration of other drugs to reduce the level of glucose is an essential approach for a better glycemic control.Objective: The aim of this study was to compare the effects of FLUOXETINE and ALPRAZOLAM added to regular anti-diabetic drugs on BLOOD GLUCOSE in patients with type 2 diabetes.Methods: In this paralleled clinical trial, 66 uncontrolled type 2 diabetic patients referred to Yazd Diabetes Research Center were selected and received randomly either 20mg of FLUOXETINE or 0.5mg of ALPRAZOLAM for 6 weeks. Mean FBS (fasting blood sugar), 2hpp (2 hours post-prandial glucose), HbAlc (Glycated Hemoglobin) and BMI (Body Mass Index) were measured before and after the study. Data were analyzed by Hest and paired Hest.Findings: The mean FBS, 2hpp, HbAlc and BMI were decreased after using FLUOXETINE by 27.5±7.5mg/dl 47.5±10.5, 1.5±0.5% and 2.2±0.8kg/m2 respectively (P=0.001). Also the mean FBS, 2hpp and HbAlc were decreased by 13.7±13.5mg/dl, 22.5±5.6 mg/dl and 0.5±0.3% following the administration of ALPRAZOLAM (P=0.001). Similarly the mean BMI was increased by 0.3±1.5 kg/m2 this difference was found to be statistically insignificant (P=0.35).Conclusion: Both FLUOXETINE and ALPRAZOLAM were useful for better control of BLOOD GLUCOSE in diabetics who were free of diabetic complications; nevertheless, it seems that FLUOXETINE is more effective than ALPRAZOLAM.

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References

EFFECTS OF ALPRAZOLAM ON FADING BLOOD SUGAR IN TYPE LL DIABETICS

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APA: Copy

AFKHAMI ARDEKANI, MOHAMMAD, SHOJA ALDINI ARDAKANI, A., SOLTANI, V., & MOLA NOURI, E.. (2008). COMPARING THE EFFECTS OF FLUOXETINE AND ALPRAZOLAM ON BLOOD GLUCOSE IN PATIENTS WITH TYPE 2 DIABETES. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), 12(1 (46)), 21-26. SID. https://sid.ir/paper/48807/en

Vancouver: Copy

AFKHAMI ARDEKANI MOHAMMAD, SHOJA ALDINI ARDAKANI A., SOLTANI V., MOLA NOURI E.. COMPARING THE EFFECTS OF FLUOXETINE AND ALPRAZOLAM ON BLOOD GLUCOSE IN PATIENTS WITH TYPE 2 DIABETES. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2008;12(1 (46)):21-26. Available from: https://sid.ir/paper/48807/en

IEEE: Copy

MOHAMMAD AFKHAMI ARDEKANI, A. SHOJA ALDINI ARDAKANI, V. SOLTANI, and E. MOLA NOURI, “COMPARING THE EFFECTS OF FLUOXETINE AND ALPRAZOLAM ON BLOOD GLUCOSE IN PATIENTS WITH TYPE 2 DIABETES,” JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), vol. 12, no. 1 (46), pp. 21–26, 2008, [Online]. Available: https://sid.ir/paper/48807/en

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