INVESTIGATION OF INSULIN RESISTANCE IN PATIENTS WITH LIVER CIRRHOSIS AND ITS RELATIONSHIP WITH SEVERITY OF DISEASE

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GHARAVI A.A.S.; HAJAGHA MOHAMMADI A.A.; ZIAEI AMIR; SAROUKHANI M.R.; JAVADI AMIR; HAGHAZALI S.

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Journal: Journal of Inflammatory Diseases Year:2008 | Volume:12 | Issue:1 (46) Page(s): 27-32

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Title

INVESTIGATION OF INSULIN RESISTANCE IN PATIENTS WITH LIVER CIRRHOSIS AND ITS RELATIONSHIP WITH SEVERITY OF DISEASE

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Keywords

LIVER CIRRHOSISQ3

INSULINQ2

INSULIN RESISTANCEQ1

LIVER FUNCTION TESTSQ3

Abstract

Background: INSULIN resistance and glucose intolerance are commonly associated with LIVER CIRRHOSIS. Resistance to INSULIN is an important prognostic factor in LIVER CIRRHOSIS.Objective: To determine the relationship between INSULIN resistance and severity of LIVER CIRRHOSIS. Methods: This was a descriptive-analytic study carried out on 76 patients with established LIVER CIRRHOSIS in Booali hospital (Qazvin) in 2006 and 2007. Their fasting blood sugar, serum INSULIN level and oral glucose tolerance test (OGTT) were measured. Patients divided into three groups of A, B and C according to the child-pugh classification. INSULIN resistance was determined by the homeostasis model assessment (HOMA-IR) in all patients. Data analysis was performed using t test, variance analysis, chi-square and Fisher's exact test.Findings: Cirrhosis was found to be strongly associated with INSULIN resistance (60.5%) and the values obtained for prevalence of INSULIN resistance for groups A, B, and C of Child-Pugh Classification were %31.6, %66.7 and %74.1, respectively. The relationship between IR and severity of LIVER CIRRHOSIS was significant, statistically (p=0.01). Diabetes mellitus was diagnosed in 26 subjects (34.2%), impaired glucose tolerance in 24 (31.6%) and normal glucose tolerance in 26 (34.2%) using OGTT.Conclusion: INSULIN resistance increased with stage of LIVER CIRRHOSIS as defined by Child-Pugh score.

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APA: Copy

GHARAVI, A.A.S., HAJAGHA MOHAMMADI, A.A., ZIAEI, AMIR, SAROUKHANI, M.R., JAVADI, AMIR, & HAGHAZALI, S.. (2008). INVESTIGATION OF INSULIN RESISTANCE IN PATIENTS WITH LIVER CIRRHOSIS AND ITS RELATIONSHIP WITH SEVERITY OF DISEASE. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), 12(1 (46)), 27-32. SID. https://sid.ir/paper/48816/en

Vancouver: Copy

GHARAVI A.A.S., HAJAGHA MOHAMMADI A.A., ZIAEI AMIR, SAROUKHANI M.R., JAVADI AMIR, HAGHAZALI S.. INVESTIGATION OF INSULIN RESISTANCE IN PATIENTS WITH LIVER CIRRHOSIS AND ITS RELATIONSHIP WITH SEVERITY OF DISEASE. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2008;12(1 (46)):27-32. Available from: https://sid.ir/paper/48816/en

IEEE: Copy

A.A.S. GHARAVI, A.A. HAJAGHA MOHAMMADI, AMIR ZIAEI, M.R. SAROUKHANI, AMIR JAVADI, and S. HAGHAZALI, “INVESTIGATION OF INSULIN RESISTANCE IN PATIENTS WITH LIVER CIRRHOSIS AND ITS RELATIONSHIP WITH SEVERITY OF DISEASE,” JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), vol. 12, no. 1 (46), pp. 27–32, 2008, [Online]. Available: https://sid.ir/paper/48816/en

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