BIOCHEMICAL MARKERS TROPONIN I, LEPTIN AND CK-MB IN CORONARY ARTERY DISEASES

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NABATCHIAN F.; EINOLLAHI N.; DASHTI N.; SARRAFNEJAD F.; KAZEMI KHALEDI A.

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Journal: Journal of Inflammatory Diseases Year:2010 | Volume:14 | Issue:1 (54) Page(s): 12-17

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Title

BIOCHEMICAL MARKERS TROPONIN I, LEPTIN AND CK-MB IN CORONARY ARTERY DISEASES

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Keywords

CARDIAC TROPONIN IQ3

LEPTINQ2

MYOCARDIAL INFARCTIONQ3

CK-MBQ3

CORONARY ARTERY DISEASESQ3

Abstract

Background: In recent years, troponin I has been a prognostic factor of myocardial cell injury. Also, regarding the importance of LEPTIN measurement in coronary artery disease investigations are being performed. In addition, CK-MB has been a "gold standard" test for this disease. Objective: The aim of this study was to assess the biochemical markers Troponin I, LEPTIN and CK-MB in CORONARY ARTERY DISEASES.Methods: This was a study on 100 patients who suffered from coronary artery disease. Following blood collection, the serum sample was tested to determine the concentration of troponin I, LEPTIN, and CK-MB. Troponin I level was measured by two-site immunoluminometric assay. LEPTIN and CK-MB levels were detected by ELISA. Statistical t-test was employed to analyze the data.Findings: The data obtained in the present study was indicative of a significant correlation between troponin I and LEPTIN among the patients (p=0.01). Also, a significant relationship was observed between troponin I and CK-MB in our study population (p=0.01). In addition, there was a significant relationship between both LEPTIN and troponin 1 and the gender (p<0.001; p<0.016). LEPTIN was also found to have a significant association with age (p=0.018). Finally, a significant correlation between the history of MYOCARDIAL INFARCTION and gender was demonstrated (p<0.002).Conclusion: Our results showed that the measurement of troponin I in combination with CK-MB, as gold standard, could be considered as an appropriate diagnostic method for progress of MYOCARDIAL INFARCTION. LEPTIN and troponin I are also suitable biomarkers in diagnosis of CORONARY ARTERY DISEASES. Due to lack of troponin I in other body tissues except for cardiac tissue, troponin I is proposed as an ideal marker for definite diagnosis of acute MYOCARDIAL INFARCTION.

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INVESTIGATION OF THE LEVEL OF SERUM TROPONIN I AND COMPARING IT WITH SERUM CK-MB IN DIAGNOSIS OF MYOCARDIAL INFARCTION

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APA: Copy

NABATCHIAN, F., EINOLLAHI, N., DASHTI, N., SARRAFNEJAD, F., & KAZEMI KHALEDI, A.. (2010). BIOCHEMICAL MARKERS TROPONIN I, LEPTIN AND CK-MB IN CORONARY ARTERY DISEASES. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), 14(1 (54)), 12-17. SID. https://sid.ir/paper/48836/en

Vancouver: Copy

NABATCHIAN F., EINOLLAHI N., DASHTI N., SARRAFNEJAD F., KAZEMI KHALEDI A.. BIOCHEMICAL MARKERS TROPONIN I, LEPTIN AND CK-MB IN CORONARY ARTERY DISEASES. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2010;14(1 (54)):12-17. Available from: https://sid.ir/paper/48836/en

IEEE: Copy

F. NABATCHIAN, N. EINOLLAHI, N. DASHTI, F. SARRAFNEJAD, and A. KAZEMI KHALEDI, “BIOCHEMICAL MARKERS TROPONIN I, LEPTIN AND CK-MB IN CORONARY ARTERY DISEASES,” JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), vol. 14, no. 1 (54), pp. 12–17, 2010, [Online]. Available: https://sid.ir/paper/48836/en

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