HYPOTHYROIDISM AND TYPE 1 DIABETES MELLITUS

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SHEYKH ALESLAMI H.; ZIAEI A.; DARVISH GHADERI S.; VAHEDI S.

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Journal: Journal of Inflammatory Diseases Year:2007 | Volume:11 | Issue:3 (44) Page(s): 51-56

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Title

HYPOTHYROIDISM AND TYPE 1 DIABETES MELLITUS

Author(s)

SHEYKH ALESLAMI H. | ZIAEI A. | DARVISH GHADERI S. | VAHEDI S. | Issue Writer Certificate

Keywords

TYPE 1 DIABETES MELLITUSQ2

HYPOTHYROIDISMQ4

ANTI THYROID PEROXIDASE ANTIBODYQ3

Abstract

Background: TYPE 1 DIABETES MELLITUS is frequently associated with autoimmune thyroid disease.Genetic susceptibility to autoantibody formation in association with autoimmune thyroid disease and TYPE 1 DIABETES MELLITUS has been described with varying frequencies.Objective: To investigate the prevalence of anti-thyroid peroxidase (anti-TPO) and also the overt and subclinical HYPOTHYROIDISM in type 1 diabetic patients.Methods: In this case-control study, 65 subjects with TYPE 1 DIABETES MELLITUS and 65 unrelated normal controls were recruited for detection of anti-TPO and thyroid-stimulating hormone (TSH). Radioimmunoassay (RIA) was used for anti-TPO and TSH detection.Findings: Out of 65 type 1 diabetic patients, 18 (27.7%) were positive for anti-TPO and 18 (27.7%) with abnormal serum TSH level. Among the patient group, 11 (16%) were found to have overt HYPOTHYROIDISM and 7 (10.8%) with subclinical HYPOTHYROIDISM. The mean anti-TPO levels were higher in patients with overt HYPOTHYROIDISM (238.18±223.69 U/ml) than in patients with subclinical HYPOTHYROIDISM (36.38±22.46 U/ml). Of a total of 11 patients with overt HYPOTHYROIDISM, 9 (81.1%) showed abnormal anti-TPO levels, whereas positive anti-TPO was detected in 57% (4 out of 7) of patients with subclinical HYPOTHYROIDISM.Conclusion: The presence of anti-TPO in 27.7% of type 1 diabetic patients confirmed a strong association between autoimmune thyroid disease and TYPE 1 DIABETES MELLITUS. Thus, for early detection of autoimmune thyroid disease in patients with TYPE 1 DIABETES MELLITUS, the measurement of anti-TPO and TSH, preferably at the onset of disease, is recommended.

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APA: Copy

SHEYKH ALESLAMI, H., ZIAEI, A., DARVISH GHADERI, S., & VAHEDI, S.. (2007). HYPOTHYROIDISM AND TYPE 1 DIABETES MELLITUS. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), 11(3 (44)), 51-56. SID. https://sid.ir/paper/49287/en

Vancouver: Copy

SHEYKH ALESLAMI H., ZIAEI A., DARVISH GHADERI S., VAHEDI S.. HYPOTHYROIDISM AND TYPE 1 DIABETES MELLITUS. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2007;11(3 (44)):51-56. Available from: https://sid.ir/paper/49287/en

IEEE: Copy

H. SHEYKH ALESLAMI, A. ZIAEI, S. DARVISH GHADERI, and S. VAHEDI, “HYPOTHYROIDISM AND TYPE 1 DIABETES MELLITUS,” JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), vol. 11, no. 3 (44), pp. 51–56, 2007, [Online]. Available: https://sid.ir/paper/49287/en

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