EFFECT OF PPARγ HIS447HIS POLYMORPHISM ON OOCYTES AND FERTILIZATION IN IVF

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SAHMANI M.; NOURI MOHAMMAD; SAKHINIA E.; FARZADI L.; SIRATI SABET M.; NAJAFIPOUR R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Inflammatory Diseases Year:2011 | Volume:14 | Issue:4 (57) Page(s): 6-11

Download Full-Text

Persian Verion

View:

641

Download:

Cites:

Information Journal Paper

Title

EFFECT OF PPARγ HIS447HIS POLYMORPHISM ON OOCYTES AND FERTILIZATION IN IVF

Author(s)

Keywords

IN VITRO FERTILIZATIONQ2

PPARQ3

HIS447HIS POLYMORPHISMQ3

Abstract

Background: Genetic factors play an important role in women fertility and embryonic development which may contribute to the efficacy of assisted reproduction techniques. Objective:The aim of this study was to investigate the effect of peroxisome proliferator-activated receptor g (PPARg) HIS447HIS POLYMORPHISM on oocytes and fertilization in women undergoing IVF. Methods:Blood samples were obtained from 98 IVF patients referred to Tabriz Alzahra Hospital. Samples were analyzed for the PPARg gene polymorphism using polymerase chain reaction-restriction fragment length polymorphism-based methods. Multivariate analyses were used to test the independence of associations between the number of mature oocytes and the number of oocytes fertilized as outcome variables and polymorphism of PPARg gene. Findings:Correlation analysis showed a significant inverse correlation between the age of women and the number of mature oocytes retrieved (r=-0.37, P=0.001) and oocytes fertilizaed (r=-0.25, P=0.015). The ratio of the number of mature oocytes to oocytes fertilizaed was significantly (P<0.05) increased in carriers of the rare alleles than homozygous wild-type genotypes. The association of HIS447HIS POLYMORPHISM (P=0.003) remained statistically significant after adjustment for confounding factors in the multivariate analyses. Conclusion:This study presents evidences that the HIS447HIS POLYMORPHISM of PPARg plays an important independent role in fertilization in vitro and thus possibly in female fertility.

Cites

No record.

References

No record.

Cite

APA: Copy

SAHMANI, M., NOURI, MOHAMMAD, SAKHINIA, E., FARZADI, L., SIRATI SABET, M., & NAJAFIPOUR, R.. (2011). EFFECT OF PPARγ HIS447HIS POLYMORPHISM ON OOCYTES AND FERTILIZATION IN IVF. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), 14(4 (57)), 6-11. SID. https://sid.ir/paper/49354/en

Vancouver: Copy

SAHMANI M., NOURI MOHAMMAD, SAKHINIA E., FARZADI L., SIRATI SABET M., NAJAFIPOUR R.. EFFECT OF PPARγ HIS447HIS POLYMORPHISM ON OOCYTES AND FERTILIZATION IN IVF. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2011;14(4 (57)):6-11. Available from: https://sid.ir/paper/49354/en

IEEE: Copy

M. SAHMANI, MOHAMMAD NOURI, E. SAKHINIA, L. FARZADI, M. SIRATI SABET, and R. NAJAFIPOUR, “EFFECT OF PPARγ HIS447HIS POLYMORPHISM ON OOCYTES AND FERTILIZATION IN IVF,” JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), vol. 14, no. 4 (57), pp. 6–11, 2011, [Online]. Available: https://sid.ir/paper/49354/en

Related Journal Papers