PLACE OF PRIMARY CHEMOTHERAPY IN NONMETASTATIC HEAD AND NECK EPIDRMOID CARCINOMA

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GHAVAM NASIRI M.R.; SALEK R.

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Journal: IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY Year:2004 | Volume:16 | Issue:2 (36) Page(s): 44-49

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Title

PLACE OF PRIMARY CHEMOTHERAPY IN NONMETASTATIC HEAD AND NECK EPIDRMOID CARCINOMA

Author(s)

GHAVAM NASIRI M.R. | SALEK R. | Issue Writer Certificate

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Abstract

Primary chemothrapy as a curative treatment always has been considered in nonmetastatic head and neck carcinoma with the purposes of improving locoregional control, decreasing probability of distant metastasis and improving overall survival. Although its improving effect on locoregional control and increasing probability of organ preservation, especially in laryngeal carcinoma has been shown and there are many reports which suggest at least delyaing distant metastasis with primary chemotherapy however randomized controlled trials have not yet reported significant improvement of overall survival. Though many of these studies have some essentail structural faults, a curative chemotherpy on its own has a relative effect that means with every chemotherapy course one log of tumor cells dies and in spite of several courses it never sterile the tumor. In additon available chemotherapy drugs, single or in combination are not the most effective ones and studies to find more effective drugs continue. On the other hand, locoregional recurrence-synchronous or earlier than metastasis-that is verycommon with low potency locoregional treatments in locally advanced head and neck carcinomas compromise the limiting effect of chemotherapy on overall survival. While enthusiasm on neoadjuvant and concurrent chemotherapy is raising nowadays, and both involve in organ preservation treatments only the latter has a relative effect on survival improvement. Therefore concurrent chemoradiotherapy with insistence on keeping dose intensity of both modalitties while increasing acute but not delayed normal tissue toxicities is the promising measure for operable or inoperable stage III and non metastatic stagelV head and neck carcinomas.

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APA: Copy

GHAVAM NASIRI, M.R., & SALEK, R.. (2004). PLACE OF PRIMARY CHEMOTHERAPY IN NONMETASTATIC HEAD AND NECK EPIDRMOID CARCINOMA . IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY, 16(2 (36)), 44-49. SID. https://sid.ir/paper/49566/en

Vancouver: Copy

GHAVAM NASIRI M.R., SALEK R.. PLACE OF PRIMARY CHEMOTHERAPY IN NONMETASTATIC HEAD AND NECK EPIDRMOID CARCINOMA . IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY[Internet]. 2004;16(2 (36)):44-49. Available from: https://sid.ir/paper/49566/en

IEEE: Copy

M.R. GHAVAM NASIRI, and R. SALEK, “PLACE OF PRIMARY CHEMOTHERAPY IN NONMETASTATIC HEAD AND NECK EPIDRMOID CARCINOMA ,” IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY, vol. 16, no. 2 (36), pp. 44–49, 2004, [Online]. Available: https://sid.ir/paper/49566/en

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