EVALUATION OF EFFECT OF TOPICAL PHENYTOIN ON WOUND HEALING (INCREASING WOUND TENSILE STRENGTH AND COLLAGEN DEPOSITION) IN RATS

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TAVASOLI ALI REZA; KADKHODAEIAN S.; NAGHIBZADEH M.; KHADIVI BANA E.

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Paper Information

Journal: IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY Year:2004 | Volume:16 | Issue:2 (36) Page(s): 7-12

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Title

EVALUATION OF EFFECT OF TOPICAL PHENYTOIN ON WOUND HEALING (INCREASING WOUND TENSILE STRENGTH AND COLLAGEN DEPOSITION) IN RATS

Author(s)

TAVASOLI ALI REZA | KADKHODAEIAN S. | NAGHIBZADEH M. | KHADIVI BANA E. | Issue Writer Certificate

Keywords

PHENYTOIN; WOUND TENSILE STRENGTH; WOUND HEALING; COLLAGEN DEPOSITION.Q3

Abstract

Background: Delyed healing and dehiscence of operative wounds represent a significant clinical problem. Sporadic reports indicate that phenytoin may significantly promote wound healing following topical application. Material & Methods: Ten male rats each received 4 dorsal skin incisions and were sutured immediately on proliferative and early maturation phase. The incisions were infiltrated with phenytoin or normal saline for controls randomly. The wounds were harvested 18 days after wounding and were assessed by tensiometric measurement and microscopic examination. Data was expressed as mean (sd) and were analysed using student"s paired T test. Results: Application of phenytoin, in both proliferative and maturation phases, resulted in a significant increase in wound tensile strength [34.16(8.15) Nand 32.18 (7.43) N in treated wound versus 28.58 Nand 26.7(4.93) N controls respectively. n=20; P<0.01]. Application of phenytoin in these two phases had no difference. The rise in wound tensile strength was associated with increase in wound collagen deposition.

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APA: Copy

TAVASOLI, ALI REZA, KADKHODAEIAN, S., NAGHIBZADEH, M., & KHADIVI BANA, E.. (2004). EVALUATION OF EFFECT OF TOPICAL PHENYTOIN ON WOUND HEALING (INCREASING WOUND TENSILE STRENGTH AND COLLAGEN DEPOSITION) IN RATS . IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY, 16(2 (36)), 7-12. SID. https://sid.ir/paper/49567/en

Vancouver: Copy

TAVASOLI ALI REZA, KADKHODAEIAN S., NAGHIBZADEH M., KHADIVI BANA E.. EVALUATION OF EFFECT OF TOPICAL PHENYTOIN ON WOUND HEALING (INCREASING WOUND TENSILE STRENGTH AND COLLAGEN DEPOSITION) IN RATS . IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY[Internet]. 2004;16(2 (36)):7-12. Available from: https://sid.ir/paper/49567/en

IEEE: Copy

ALI REZA TAVASOLI, S. KADKHODAEIAN, M. NAGHIBZADEH, and E. KHADIVI BANA, “EVALUATION OF EFFECT OF TOPICAL PHENYTOIN ON WOUND HEALING (INCREASING WOUND TENSILE STRENGTH AND COLLAGEN DEPOSITION) IN RATS ,” IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY, vol. 16, no. 2 (36), pp. 7–12, 2004, [Online]. Available: https://sid.ir/paper/49567/en

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