EVALUATION OF IL-17 GENE EXPRESSION IN THE PERIPHERAL BLOOD OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY

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YAZDANI REZA; GANJALIKHANI HAKEMI MAZDAK; SHERKAT ROYA; MASJEDI MOHSEN; ZARKESH HAMID; HOSSEINI MOHSEN

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Journal: Journal of Isfahan Medical School Year:2013 | Volume:31 | Issue:230 Page(s): 358-363

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Title

EVALUATION OF IL-17 GENE EXPRESSION IN THE PERIPHERAL BLOOD OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY

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Keywords

COMMON VARIABLE IMMUNODEFICIENCYQ2

CYTOKINQ2

IL-17Q2

TH17Q2

REAL TIME-PCRQ2

Abstract

Background: Producing IL-17, TH17 cells induce BAFF and APRIL, two important mediators for Bcell survival and activation. COMMON VARIABLE IMMUNODEFICIENCY (CVID) is a group of many primary immunodeficiency diseases with a common set of features (including hypo-gammaglobulinemia) and different underlying causes. The prevalence of CVID is 1 to 50, 000. Hence, the aim of this study was to measure IL-17 gene expression in peripheral blood of patients with CVID.Methods: Total mRNA extracted from whole blood samples of 10 patients with CVID and 10 normal controls; then, IL-17 gene was measured using qRT-PCR.Findings: There was a slight decrease in transcript levels of IL-17 in patients with CVID, even though, it was not statistically significant (P=0.195).Conclusion: We showed that IL-17 is decreased in patients with CVID and this could be an explanation for their humoral immunity response insufficiencies. Absence of statistical significance in this IL-17 reduction may be due to our sample size and increasing the number of samples may result in statistical significance of this in future studies.

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APA: Copy

YAZDANI, REZA, GANJALIKHANI HAKEMI, MAZDAK, SHERKAT, ROYA, MASJEDI, MOHSEN, ZARKESH, HAMID, & HOSSEINI, MOHSEN. (2013). EVALUATION OF IL-17 GENE EXPRESSION IN THE PERIPHERAL BLOOD OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 31(230), 358-363. SID. https://sid.ir/paper/49598/en

Vancouver: Copy

YAZDANI REZA, GANJALIKHANI HAKEMI MAZDAK, SHERKAT ROYA, MASJEDI MOHSEN, ZARKESH HAMID, HOSSEINI MOHSEN. EVALUATION OF IL-17 GENE EXPRESSION IN THE PERIPHERAL BLOOD OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2013;31(230):358-363. Available from: https://sid.ir/paper/49598/en

IEEE: Copy

REZA YAZDANI, MAZDAK GANJALIKHANI HAKEMI, ROYA SHERKAT, MOHSEN MASJEDI, HAMID ZARKESH, and MOHSEN HOSSEINI, “EVALUATION OF IL-17 GENE EXPRESSION IN THE PERIPHERAL BLOOD OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 31, no. 230, pp. 358–363, 2013, [Online]. Available: https://sid.ir/paper/49598/en

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