THE EVALUATION OF ARG EXPRESSION IN DLBCL STAGING

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MAKARIAN F.; AMINI SHAHNAZ; KABIRI Z.; SALEHI MANSOUR

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2008 | Volume:26 | Issue:90 Page(s): 257-266

Download Full-Text

Persian Verion

View:

936

Download:

Cites:

Information Journal Paper

Title

THE EVALUATION OF ARG EXPRESSION IN DLBCL STAGING

Author(s)

MAKARIAN F. | AMINI SHAHNAZ | KABIRI Z. | SALEHI MANSOUR | Issue Writer Certificate

Keywords

LYMPHOMAQ3

ARGQ3

DLBCLQ3

Abstract

Background: ARG is a proto-oncogene and a member of a tyrosine kinase proteins family. It has great importance in many cancers, but there is no conclusive evidence on its role in DLBCL staging. The aim of this study was to evaluate importance of ARG, in this cancer's staging.Methods: Sixteen DLBCL and 4 reactive lymph node (as control group) samples, after staging using Ann Arbor staging system, were used in this study. Formaldehyde fixed paraffin embedded blocks were prepared from the samples. After the sectioning, all samples were hybridized with primary antibodies against ARG and GAPDH (as control house keep keeping gene). The slides were then washed and hybridized with fluorescently labeled secondary antibodies (ARG, green labeled and GAPDH, red). After capturing the pictures using CCD camera, the intensity of green and red colures was measured and the ratio between green/red, that demonstrate changes in ARG expression, were calculated.Findings: The mean ratio of green/red (ARG expression) was significantly different between reactive lymph node, stage I, II and III of DLBCL. ARG expression was different between all groups except for between stage III and VI of DLBCL.Conclusion: The observed changes in ARG expression is a potential biomarker for DLBCL staging. In addition specific inhibitors of ARG can be considered as new chemotherapy agents in the DLBCL treatment.

Cites

No record.

References

No record.

Cite

APA: Copy

MAKARIAN, F., AMINI, SHAHNAZ, KABIRI, Z., & SALEHI, MANSOUR. (2008). THE EVALUATION OF ARG EXPRESSION IN DLBCL STAGING. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 26(90), 257-266. SID. https://sid.ir/paper/49824/en

Vancouver: Copy

MAKARIAN F., AMINI SHAHNAZ, KABIRI Z., SALEHI MANSOUR. THE EVALUATION OF ARG EXPRESSION IN DLBCL STAGING. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2008;26(90):257-266. Available from: https://sid.ir/paper/49824/en

IEEE: Copy

F. MAKARIAN, SHAHNAZ AMINI, Z. KABIRI, and MANSOUR SALEHI, “THE EVALUATION OF ARG EXPRESSION IN DLBCL STAGING,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 26, no. 90, pp. 257–266, 2008, [Online]. Available: https://sid.ir/paper/49824/en

Related Journal Papers