مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

REVIEW ARTICLE: AN OVERVIEW OF PEPTIDE NUCLEIC ACIDS: STRUCTURE, PROPERTIES, AND APPLICATIONS

Pages

  2390-2402

Abstract

 For decades, nucleic acid analogues have been emerged in molecular biology. Some of these analogues are powerful bimolecular tools in biotechnology. Among the four major classes of these synthetic molecules (XNA: xenonucleic acid, LNA: locked nucleic acid, PNA: peptide nucleic acid and morpholino), PNA is the most important. In PNA, N-aminoethyle glycine units (to which purine/pyrimidine bases have been attached), are joined together to form an achiral and peptide-like STRUCTURE that mimics the behavior of DNA and can hybridize to nucleic acid and to other PNA in sequence specific manner. Because of its unique physicochemical properties, PNA in many cases prefers over natural oligonucleotide and therefore, have been exploited in some strategies and methods in the field of diagnostics and therapy. In this review, we describe the STRUCTURE, BIOCHEMICAL PROPERTIES, and BIOMEDICAL APPLICATIONS of PNA.

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  • Cite

    APA: Copy

    FARROKHIFARD, AREF, & KHEIROLLAHI, MAJID. (2014). REVIEW ARTICLE: AN OVERVIEW OF PEPTIDE NUCLEIC ACIDS: STRUCTURE, PROPERTIES, AND APPLICATIONS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 31(270), 2390-2402. SID. https://sid.ir/paper/49859/en

    Vancouver: Copy

    FARROKHIFARD AREF, KHEIROLLAHI MAJID. REVIEW ARTICLE: AN OVERVIEW OF PEPTIDE NUCLEIC ACIDS: STRUCTURE, PROPERTIES, AND APPLICATIONS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2014;31(270):2390-2402. Available from: https://sid.ir/paper/49859/en

    IEEE: Copy

    AREF FARROKHIFARD, and MAJID KHEIROLLAHI, “REVIEW ARTICLE: AN OVERVIEW OF PEPTIDE NUCLEIC ACIDS: STRUCTURE, PROPERTIES, AND APPLICATIONS,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 31, no. 270, pp. 2390–2402, 2014, [Online]. Available: https://sid.ir/paper/49859/en

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