THE EFFECT OF A FOUR- WEEK AEROBIC ACTIVITY IN WATER ON THE EXTENT OF CLINICAL IMPROVEMENT AND NEUREGULIN-1 (NRG1) PROTEIN IN THE BRAIN TISSUE OF ANIMAL MODEL OF MULTIPLE SCLEROSIS (MS) VIA INDUCING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS (EAE)

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MOUSAVI SEYED ROUHOLLAH; RAJABI HAMID; GHADIRI ATAALLAH; GHARAKHANLOU REZA; SARKAKI ALIREZA

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2017 | Volume:35 | Issue:447 Page(s): 1233-1241

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Title

THE EFFECT OF A FOUR- WEEK AEROBIC ACTIVITY IN WATER ON THE EXTENT OF CLINICAL IMPROVEMENT AND NEUREGULIN-1 (NRG1) PROTEIN IN THE BRAIN TISSUE OF ANIMAL MODEL OF MULTIPLE SCLEROSIS (MS) VIA INDUCING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS (EAE)

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Keywords

NEUREGULIN-1Q1

AEROBIC EXERCISESQ2

MULTIPLE SCLEROSISQ1

Abstract

Background: This study was conducted to investigate the effect of a four- week aerobic physical activity in water on the extent of clinical improvement and amount of NEUREGULIN-1 (NRG1) protein in the brain tissue of animal model of MULTIPLE SCLEROSIS (MS) via inducing experimental autoimmune encephalomyelitis (EAE).Methods: To this end, a total number of 80 female Syrian mice from the race of C57BL/6, aging 10 to 12 weeks and weighing 20±2 gram were divided into eight groups of 10, namely, control, swimming, MS, MS + swimming, MS + interferon beta (INF-b), MS + solvent, and MS + solvent + swimming environment. For induction of EAE, 300 mg (35-55) myelin oligodendrocyte glycoprotein (MOG) was first mixed in 100 ml phosphate buffered saline (PBS) with complete Freund's adjuvant (CFA) and injected subcutaneously (SC). At the time of injection and after 48 hours, 300 ng pertussis toxin was diluted in PBS and injected intraperitoneally (IP). During a week after the treatment, mice recieving the drug in form of intraperitoneal received 150 IU/g of the drug per day. Clinical symptoms and the mice's weights were recorded every day. Physical activity group did the aerobic activities for four weeks, five sessions a week, 30 minutes each session. Standard scoring system was used for clinical check and enzyme- linked immunosorbent assay (ELISA) was applied to measure NRG1 protein. Data analysis was done using one- way ANOVA.Findings: The effect of physical activity in water on treatment of MULTIPLE SCLEROSIS was the same as that of interferon. The amount of rise in NRG1 protein in swimming group was more than that of the interferon group.Conclusion: Aerobic swimming exercises could probably help remyelination by increasing the amount of NRG1 protein and lowering the speed of myelin destruction, hence, helping the clinical improvement in patients with MULTIPLE SCLEROSIS.

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APA: Copy

MOUSAVI, SEYED ROUHOLLAH, RAJABI, HAMID, GHADIRI, ATAALLAH, GHARAKHANLOU, REZA, & SARKAKI, ALIREZA. (2017). THE EFFECT OF A FOUR- WEEK AEROBIC ACTIVITY IN WATER ON THE EXTENT OF CLINICAL IMPROVEMENT AND NEUREGULIN-1 (NRG1) PROTEIN IN THE BRAIN TISSUE OF ANIMAL MODEL OF MULTIPLE SCLEROSIS (MS) VIA INDUCING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS (EAE). JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 35(447 ), 1233-1241. SID. https://sid.ir/paper/49875/en

Vancouver: Copy

MOUSAVI SEYED ROUHOLLAH, RAJABI HAMID, GHADIRI ATAALLAH, GHARAKHANLOU REZA, SARKAKI ALIREZA. THE EFFECT OF A FOUR- WEEK AEROBIC ACTIVITY IN WATER ON THE EXTENT OF CLINICAL IMPROVEMENT AND NEUREGULIN-1 (NRG1) PROTEIN IN THE BRAIN TISSUE OF ANIMAL MODEL OF MULTIPLE SCLEROSIS (MS) VIA INDUCING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS (EAE). JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2017;35(447 ):1233-1241. Available from: https://sid.ir/paper/49875/en

IEEE: Copy

SEYED ROUHOLLAH MOUSAVI, HAMID RAJABI, ATAALLAH GHADIRI, REZA GHARAKHANLOU, and ALIREZA SARKAKI, “THE EFFECT OF A FOUR- WEEK AEROBIC ACTIVITY IN WATER ON THE EXTENT OF CLINICAL IMPROVEMENT AND NEUREGULIN-1 (NRG1) PROTEIN IN THE BRAIN TISSUE OF ANIMAL MODEL OF MULTIPLE SCLEROSIS (MS) VIA INDUCING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS (EAE),” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 35, no. 447 , pp. 1233–1241, 2017, [Online]. Available: https://sid.ir/paper/49875/en

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