EFFECT OF DOSE DEPENDENT CIGARETTE SMOKING ON QTC INTERVAL AND QTCDISPERSION IN MEN

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SANEEI H.; KHARRAS M.; HASHEMI M.; HEIDARI R.

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2004 | Volume:21 | Issue:71 Page(s): 1-5

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Title

EFFECT OF DOSE DEPENDENT CIGARETTE SMOKING ON QTC INTERVAL AND QTCDISPERSION IN MEN

Author(s)

SANEEI H. | KHARRAS M. | HASHEMI M. | HEIDARI R. | Issue Writer Certificate

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Abstract

Introduction. Cardiovascular disease is a major public health problem in developing and developed countries. Smoking is themost modifiable risk factor for atherosclerotic heart disease. Acute cardiac events such as ventricular fibrillation and sudden cardiac death are increased by cigarette smoking and QT interval prologation associated with a lowered threshold of this events.Methods. The study included a sample of 160 healthy subjects of 20-59 year old men in four groups. First group was nonsmoker and others were smoker (<10, 10-20,>20 pack - year). all subjectswere age - matched.All subjects underwent a routine 12-lead electrocardiogram at rest. Then QT interval and QT dispersion were measured and corrected by bazett, fridercia and linear regression formulas. Comparison of data between these groups was performed with the ANOVA test.Results. Corrected QTc max was significantly increased in smokers compared with nonsmokers (P<0.00l) and in >20 pack - year smokers was significantly increased compared with <10 pack - year smokers (P<0.00l). QTc dispersion was significantly increased in smokers compared with nonsmokers (P<0.00l) but there is no significant difference between smokers. Correlation between these formulas in correction of QT interval was greater than 95% in pierson test.Discussion. Smoking prolonges QTc interval and QTc dispersion. This effect together with increase in sympathetic tone and decrease in vagal tone and blunted barroreceptor gain can result increase in coronary and arrhythmogenic events in smokers.

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APA: Copy

SANEEI, H., KHARRAS, M., HASHEMI, M., & HEIDARI, R.. (2004). EFFECT OF DOSE DEPENDENT CIGARETTE SMOKING ON QTC INTERVAL AND QTCDISPERSION IN MEN. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 21(71), 1-5. SID. https://sid.ir/paper/49938/en

Vancouver: Copy

SANEEI H., KHARRAS M., HASHEMI M., HEIDARI R.. EFFECT OF DOSE DEPENDENT CIGARETTE SMOKING ON QTC INTERVAL AND QTCDISPERSION IN MEN. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2004;21(71):1-5. Available from: https://sid.ir/paper/49938/en

IEEE: Copy

H. SANEEI, M. KHARRAS, M. HASHEMI, and R. HEIDARI, “EFFECT OF DOSE DEPENDENT CIGARETTE SMOKING ON QTC INTERVAL AND QTCDISPERSION IN MEN,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 21, no. 71, pp. 1–5, 2004, [Online]. Available: https://sid.ir/paper/49938/en

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