CYTOTOXICITY EFFECT OF PINEAPPLE EXTRACT ON BREAST CANCER CELLS (4T1)

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Raeisi Farzane; Raeisi Elham; SHAHBAZI GAHROUEI DARYOUSH; HEIDARIAN ESFANDYAR; AMIRI MOHAMMAD; GHOLAMI MOSTAFA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2016 | Volume:34 | Issue:394 Page(s): 946-951

Download Full-Text

Persian Verion

View:

1,440

Download:

Cites:

Information Journal Paper

Title

CYTOTOXICITY EFFECT OF PINEAPPLE EXTRACT ON BREAST CANCER CELLS (4T1)

Author(s)

Keywords

PINEAPPLE EXTRACT (BROMELAIN)Q1

BREAST CANCER (4T1) CELLSQ1

CYTOTOXICITYQ2

Abstract

Background: Aqueous extract of pineapple (Bromelain) is used in medicine. Bromelain has anticancer effect on leukemia, lymphoma, sarcoma and melanoma. The purpose of this study was to evaluate the anticancer effect of bromelain on mouse breast cancer (4T1) cells under in-vitro conditions.Methods: Mouse breast cancer (4T1) cells were incubated with different concentrations of the bromelain for 2, 48, 24 and 72 hours. The growth-inhibitory was investigated via 3 (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium-bromide (MTT) assay. Kruskal-Wallis and Dunn’s tests were used to evaluate the statistical significance of the difference between the experimental and control groups.Findings: Bromelain significantly inhibited proliferation of 4T1 cells in a concentration-dependent manner. In all concentrations, cell viability decreased with respect to the control incubated cells in the absence of extract (P<0.05). Bromelain exerted highest antiproliferative effects on 4T1 cells for concentrations of 100, 200, 300, 400 and 600g/ml (P<0.05) for 24, 48 and 72 hours, while cell viability increased for times shorter than 2 hours. The half maximal inhibitory concentration (IC50) value of 142.6 g/ml was obtained from treating 4T1 cells Conclusion: Results showed that bromelain has cytotoxic effects on the growth and proliferation of 4T1 cells for 24, 48 and 72 hours of incubation. This study is ongoing to assess the extract mechanism of action.

Cites

No record.

References

Cite

APA: Copy

Raeisi, Farzane, Raeisi, Elham, SHAHBAZI GAHROUEI, DARYOUSH, HEIDARIAN, ESFANDYAR, AMIRI, MOHAMMAD, & GHOLAMI, MOSTAFA. (2016). CYTOTOXICITY EFFECT OF PINEAPPLE EXTRACT ON BREAST CANCER CELLS (4T1). JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 34(394), 946-951. SID. https://sid.ir/paper/50018/en

Vancouver: Copy

Raeisi Farzane, Raeisi Elham, SHAHBAZI GAHROUEI DARYOUSH, HEIDARIAN ESFANDYAR, AMIRI MOHAMMAD, GHOLAMI MOSTAFA. CYTOTOXICITY EFFECT OF PINEAPPLE EXTRACT ON BREAST CANCER CELLS (4T1). JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2016;34(394):946-951. Available from: https://sid.ir/paper/50018/en

IEEE: Copy

Farzane Raeisi, Elham Raeisi, DARYOUSH SHAHBAZI GAHROUEI, ESFANDYAR HEIDARIAN, MOHAMMAD AMIRI, and MOSTAFA GHOLAMI, “CYTOTOXICITY EFFECT OF PINEAPPLE EXTRACT ON BREAST CANCER CELLS (4T1),” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 34, no. 394, pp. 946–951, 2016, [Online]. Available: https://sid.ir/paper/50018/en

Related Journal Papers