DETERMINATION OF THE TESTOSTERONE EFFECT ON THE AVERAGE CONCENTRATION OF BASIC FIBROBLAST GROWTH FACTOR (BFGF) AND PLATELET-DERIVED GROWTH FACTOR (PDGF) IN MALE WISTAR RATS

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NASR ESFAHANI FARID; HAGHJOOY JAVANMARD SHAGHAYEGH; MOTAMER MARYAM; MORTAZAVI ZAHRA SADAT; BAHRANI SAEIDEH

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2014 | Volume:32 | Issue:272 Page(s): 9-15

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Title

DETERMINATION OF THE TESTOSTERONE EFFECT ON THE AVERAGE CONCENTRATION OF BASIC FIBROBLAST GROWTH FACTOR (BFGF) AND PLATELET-DERIVED GROWTH FACTOR (PDGF) IN MALE WISTAR RATS

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Keywords

BASIC FIBROBLAST GROWTH FACTORQ2

PLATELETQ2

DERIVED GROWTH FACTORQ2

TESTOSTERONEQ2

ANGIOGENESISQ2

Abstract

Background: ANGIOGENESIS is a determinant factor in the treatment of cardiovascular diseases. The purpose of this study was determining the effect of TESTOSTERONE on the average concentration of BASIC FIBROBLAST GROWTH FACTOR (bFGF) and PLATELET-derived growth factor (PDGF) as angiogenic stimulating factors in the blood of male rats.Methods: In this experimental study, 24 male rats were divided into 4 groups. The first group went under sham surgery (making incisions without doing any special work on rats’ bodies) and 3 others went under the orchiectomy (OCX). The first and second groups received 0.1 mg/day sesame oil as placebo and the third and fourth groups received 1 and 5 mg/kg/day TESTOSTERONE, respectively. After 21 days, the concentrations of bFGF and PDGF were measured in rats blood.Findings: The mean concentration of PDGF in rats in forth group was significantly more than those in third group (P<0.05). In addition, the mean concentration of bFGF in third group was significantly less than the others (P<0.05).Conclusion: Reduction of TESTOSTERONE causes reduction of PDGF and it may be effective on decreasing the ANGIOGENESIS potentially. Different levels of TESTOSTERONE had no effect on bFGF concentration.

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APA: Copy

NASR ESFAHANI, FARID, HAGHJOOY JAVANMARD, SHAGHAYEGH, MOTAMER, MARYAM, MORTAZAVI, ZAHRA SADAT, & BAHRANI, SAEIDEH. (2014). DETERMINATION OF THE TESTOSTERONE EFFECT ON THE AVERAGE CONCENTRATION OF BASIC FIBROBLAST GROWTH FACTOR (BFGF) AND PLATELET-DERIVED GROWTH FACTOR (PDGF) IN MALE WISTAR RATS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 32(272), 9-15. SID. https://sid.ir/paper/50131/en

Vancouver: Copy

NASR ESFAHANI FARID, HAGHJOOY JAVANMARD SHAGHAYEGH, MOTAMER MARYAM, MORTAZAVI ZAHRA SADAT, BAHRANI SAEIDEH. DETERMINATION OF THE TESTOSTERONE EFFECT ON THE AVERAGE CONCENTRATION OF BASIC FIBROBLAST GROWTH FACTOR (BFGF) AND PLATELET-DERIVED GROWTH FACTOR (PDGF) IN MALE WISTAR RATS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2014;32(272):9-15. Available from: https://sid.ir/paper/50131/en

IEEE: Copy

FARID NASR ESFAHANI, SHAGHAYEGH HAGHJOOY JAVANMARD, MARYAM MOTAMER, ZAHRA SADAT MORTAZAVI, and SAEIDEH BAHRANI, “DETERMINATION OF THE TESTOSTERONE EFFECT ON THE AVERAGE CONCENTRATION OF BASIC FIBROBLAST GROWTH FACTOR (BFGF) AND PLATELET-DERIVED GROWTH FACTOR (PDGF) IN MALE WISTAR RATS,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 32, no. 272, pp. 9–15, 2014, [Online]. Available: https://sid.ir/paper/50131/en

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