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Information Journal Paper

Title

THE ROLE OF PRO564LEU OF FXIII-A GENE POLYMORPHISM IN CENTRAL NERVOUS BLEEDING IN PATIENTS WITH CONGENITAL FACTOR XIII DEFICIENCY SOUTHEAST OF IRAN

Pages

  25-33

Keywords

CENTRAL NERVOUS SYSTEM (CNS)Q2

Abstract

 Background: The deficiency of factor XIII is a rare hemorrhagic disorder with the highest global incidence in Sistan and Baluchistan province in Iran. BLEEDING of central nervous system (CNS) is a common but life-threatening clinical presentation of severe FACTOR XIII DEFICIENCY. The aim of this study was to assess the role of PRO564LEU POLYMORPHISM in occurrence of intra- and extra-cranial hemorrhage in factor 13 deficiency.Methods: 32 patients with factor XIII deficient and history of CNS BLEEDING and 32 patients with FACTOR XIII DEFICIENCY but without CNS BLEEDING were selected as case and control groups. Initially, the baseline for the Trp187Arg polymorphism was evaluated in both groups to confirm the disorder. Then, all the patients were assessed for PRO564LEU POLYMORPHISM.Findings: All the study patients were homozygote for factor XIII polymorphism. We also found that no patient in both groups was positive for PRO564LEU POLYMORPHISM.Conclusion: It seems that PRO564LEU POLYMORPHISM do not have any effect on occurrence of CNS BLEEDING in FACTOR XIII DEFICIENCY.

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    APA: Copy

    NADERI, MAJID, DORGALALEH, AKBAR, ALIZADEH, SHABAN, KAZEMI, AHMAD, TABIBIAN, SHADI, DARGAHI, HOSSEIN, KASHANI KHATIB, ZAHRA, KAHIRI, MEYSAM, & HOSEINI, MARYAM SADAT. (2014). THE ROLE OF PRO564LEU OF FXIII-A GENE POLYMORPHISM IN CENTRAL NERVOUS BLEEDING IN PATIENTS WITH CONGENITAL FACTOR XIII DEFICIENCY SOUTHEAST OF IRAN. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 32(272), 25-33. SID. https://sid.ir/paper/50133/en

    Vancouver: Copy

    NADERI MAJID, DORGALALEH AKBAR, ALIZADEH SHABAN, KAZEMI AHMAD, TABIBIAN SHADI, DARGAHI HOSSEIN, KASHANI KHATIB ZAHRA, KAHIRI MEYSAM, HOSEINI MARYAM SADAT. THE ROLE OF PRO564LEU OF FXIII-A GENE POLYMORPHISM IN CENTRAL NERVOUS BLEEDING IN PATIENTS WITH CONGENITAL FACTOR XIII DEFICIENCY SOUTHEAST OF IRAN. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2014;32(272):25-33. Available from: https://sid.ir/paper/50133/en

    IEEE: Copy

    MAJID NADERI, AKBAR DORGALALEH, SHABAN ALIZADEH, AHMAD KAZEMI, SHADI TABIBIAN, HOSSEIN DARGAHI, ZAHRA KASHANI KHATIB, MEYSAM KAHIRI, and MARYAM SADAT HOSEINI, “THE ROLE OF PRO564LEU OF FXIII-A GENE POLYMORPHISM IN CENTRAL NERVOUS BLEEDING IN PATIENTS WITH CONGENITAL FACTOR XIII DEFICIENCY SOUTHEAST OF IRAN,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 32, no. 272, pp. 25–33, 2014, [Online]. Available: https://sid.ir/paper/50133/en

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