THE EFFECT OF POMEGRANATE EXTRACT ON PRODUCING TYPE II COLLAGEN IN DIFFERENTIATION OF ADIPOSE-DERIVED STEM CELLS INTO CHONDROCYTES

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KATANI MEHRI; ZOLFAGHARI BEHZAD; Soleimani Mitra; VALIANI ALI; HASHEMIBENI BATOOL

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2018 | Volume:35 | Issue:453 Page(s): 1540-1545

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Title

THE EFFECT OF POMEGRANATE EXTRACT ON PRODUCING TYPE II COLLAGEN IN DIFFERENTIATION OF ADIPOSE-DERIVED STEM CELLS INTO CHONDROCYTES

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Keywords

CHONDROGENESISQ2

STEM CELLSQ2

POMEGRANATEQ2

TYPE II COLLAGENQ2

Abstract

Background: Cartilage tissue is avascular and has no repairing capacity. For cartilage tissue engineering, STEM CELLS and growth factors are used. In this study, the effect of POMEGRANATE as inducer for CHONDROGENESIS of adipose-derived STEM CELLS (ADSCs) was evaluated.Methods: Human adipose-derived STEM CELLS in third passage seeded in fibrin were cultured in chondrogenic medium with POMEGRANATE for 2 weeks.3- (4, 5-dimethylthiazol-2-yl) -2, 5-diphenyltetrazolium bromide (MTT assay) and western blot technique were applied for evaluation of differentiated cells.Findings: Adipose-derived STEM CELLS differentiated into chondrocytes; and TYPE II COLLAGEN production by differentiated cells was proved.Conclusion: POMEGRANATE extract is an appropriate inducer for production of TYPE II COLLAGEN in adipose-derived STEM CELLS.

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APA: Copy

KATANI, MEHRI, ZOLFAGHARI, BEHZAD, Soleimani, Mitra, VALIANI, ALI, & HASHEMIBENI, BATOOL. (2018). THE EFFECT OF POMEGRANATE EXTRACT ON PRODUCING TYPE II COLLAGEN IN DIFFERENTIATION OF ADIPOSE-DERIVED STEM CELLS INTO CHONDROCYTES. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 35(453 ), 1540-1545. SID. https://sid.ir/paper/50136/en

Vancouver: Copy

KATANI MEHRI, ZOLFAGHARI BEHZAD, Soleimani Mitra, VALIANI ALI, HASHEMIBENI BATOOL. THE EFFECT OF POMEGRANATE EXTRACT ON PRODUCING TYPE II COLLAGEN IN DIFFERENTIATION OF ADIPOSE-DERIVED STEM CELLS INTO CHONDROCYTES. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2018;35(453 ):1540-1545. Available from: https://sid.ir/paper/50136/en

IEEE: Copy

MEHRI KATANI, BEHZAD ZOLFAGHARI, Mitra Soleimani, ALI VALIANI, and BATOOL HASHEMIBENI, “THE EFFECT OF POMEGRANATE EXTRACT ON PRODUCING TYPE II COLLAGEN IN DIFFERENTIATION OF ADIPOSE-DERIVED STEM CELLS INTO CHONDROCYTES,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 35, no. 453 , pp. 1540–1545, 2018, [Online]. Available: https://sid.ir/paper/50136/en

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