EFFECTS OF AVERRHOA CARAMBOLA HYDRO-ALCOHOLIC EXTRACT ON ACUTE LEAD-ACETATE-INDUCED LIVER TOXICITY IN RATS

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Shirazinia Reza; HAJINEZHAD MOHAMMAD REZA; JAMSHIDIAN ABBAS; SAMZADEH KERMANI ALI REZA; HASANEIN PARISA

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2017 | Volume:34 | Issue:411 Page(s): 1531-1536

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Title

EFFECTS OF AVERRHOA CARAMBOLA HYDRO-ALCOHOLIC EXTRACT ON ACUTE LEAD-ACETATE-INDUCED LIVER TOXICITY IN RATS

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Keywords

LEADQ2

LIVER TOXICITYQ1

AVERRHOA CARAMBOLAQ1

RATSQ2

Abstract

Background: In this survey, the effect of AVERRHOA CARAMBOLA fruit hydro-alcoholic extract on acute LEADacetate-induced hepatotoxicity in RATS was studied.Methods: In this experimental study, 24 male RATS were equally divided to 4 groups. The first group received normal saline orally and served as negative control, the second group received only LEAD acetate for 5 days and served as positive control group. Groups 3 and 4 were treated orally with AVERRHOA CARAMBOLA at doses of 100 and 200 mg/kg, respectively, for 10 days. These groups were also received LEAD acetate (25 mg/kg) during the last 5 days. At the end of the study, serum liver enzymes and malondialdehyde (MDA) levels were assayed.Besides, histopathological changes of liver were examined under light microscopy.Findings: Oral administration of AVERRHOA CARAMBOLA fruit extract at a dose of 100 mg/kg had no significant effect on serum levels of malondialdehyde and liver enzymes compared to positive control group. Treatment with AVERRHOA CARAMBOLA fruit extract at dose of 200 mg/kg significantly reduced serum levels of alanine transaminase (ALT) (P<0.05) and aspartate transaminase (AST) (P<0.01) in RATS compared to positive control group. Furthermore, treatment with AVERRHOA CARAMBOLA fruit extract (200 mg/kg) significantly decreased serum levels of malondialdehyde compared with the positive control group (P<0.01). The histopathological investigations revealed that treatment with AVERRHOA CARAMBOLA fruit extract (200 mg/kg) decreased hepatic necrosis and sinusoidal distention compared to negative control group.Conclusion: Results showed the protective effect of AVERRHOA CARAMBOLA fruit extract on acute LEAD-acetateinduced liver injury in RATS.

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APA: Copy

Shirazinia, Reza, HAJINEZHAD, MOHAMMAD REZA, JAMSHIDIAN, ABBAS, SAMZADEH KERMANI, ALI REZA, & HASANEIN, PARISA. (2017). EFFECTS OF AVERRHOA CARAMBOLA HYDRO-ALCOHOLIC EXTRACT ON ACUTE LEAD-ACETATE-INDUCED LIVER TOXICITY IN RATS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 34(411), 1531-1536. SID. https://sid.ir/paper/50228/en

Vancouver: Copy

Shirazinia Reza, HAJINEZHAD MOHAMMAD REZA, JAMSHIDIAN ABBAS, SAMZADEH KERMANI ALI REZA, HASANEIN PARISA. EFFECTS OF AVERRHOA CARAMBOLA HYDRO-ALCOHOLIC EXTRACT ON ACUTE LEAD-ACETATE-INDUCED LIVER TOXICITY IN RATS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2017;34(411):1531-1536. Available from: https://sid.ir/paper/50228/en

IEEE: Copy

Reza Shirazinia, MOHAMMAD REZA HAJINEZHAD, ABBAS JAMSHIDIAN, ALI REZA SAMZADEH KERMANI, and PARISA HASANEIN, “EFFECTS OF AVERRHOA CARAMBOLA HYDRO-ALCOHOLIC EXTRACT ON ACUTE LEAD-ACETATE-INDUCED LIVER TOXICITY IN RATS,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 34, no. 411, pp. 1531–1536, 2017, [Online]. Available: https://sid.ir/paper/50228/en

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