COMPARING KOJIC ACID CREAM 2% WITH GLYCOLIC ACID 10% AND HYDROQUINONE CREAM 2% IN TREATMENT OF MELASMA

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IRAJI FARIBA; ASILILAN ALI; FADAEI FATEMEH; NILFOROUSHZADEH MOHAMMAD ALI

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2014 | Volume:31 | Issue:269 (SPECIAL ISSUE (SKIN DISEASES AND LEISHMANIASIS)) Page(s): 2295-2300

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Title

COMPARING KOJIC ACID CREAM 2% WITH GLYCOLIC ACID 10% AND HYDROQUINONE CREAM 2% IN TREATMENT OF MELASMA

Author(s)

IRAJI FARIBA | ASILILAN ALI | FADAEI FATEMEH | NILFOROUSHZADEH MOHAMMAD ALI | Issue Writer Certificate

Keywords

MELASMAQ3

TREATMENT OF MELASMAQ3

TOPICAL TREATMENT OF MELASMAQ4

KOJIC ACIDQ2

Abstract

Background: MELASMA is a common acquired hypermelanosis in areas exposed to sunlight, which exacerbates with sunlight, pregnancy, and endocrine diseases. MELASMA is problematic regarding cosmetic especially in women. Many drugs have been used for its treatment, but regarding side effects, they have limited relative usage. Therefore, testing a new drug with higher effectiveness and fewer side effects is necessary. This study attempted to evaluate the effectiveness of KOJIC ACID on MELASMA.Methods: In this study double-blind clinical trial study, 40 patients with MELASMA were enroled. One group of 20 people received KOJIC ACID cream 2%, and the other used glycolic acid 10% and hydroquinone cream 2%. In the first group, 43 pigmented macules and in the second group, 21 pigmented macules existed. The changes of pigments in terms of recovery time, color tone and size of the pigments over a three-month treatment period was evaluated with clinical assessment, completing monthly questionnaire, and in a few cases with the aid of Wood's lamp. After the three-month treatment period, the collected data using the Friedman test, t-test were analyzed.Findings: In total, 79% of the patients were cured after 3 months. According to Friedman test, regarding healing time of the pigment, there was a significant difference between the groups (P=0.008). Regarding the color tone changes of the pigment at the end of the second and third months, there was a significant difference between the two groups.Conclousion: KOJIC ACID 2% cream has a good efficacy in the treatment of MELASMA with no serious complications.

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APA: Copy

IRAJI, FARIBA, ASILILAN, ALI, FADAEI, FATEMEH, & NILFOROUSHZADEH, MOHAMMAD ALI. (2014). COMPARING KOJIC ACID CREAM 2% WITH GLYCOLIC ACID 10% AND HYDROQUINONE CREAM 2% IN TREATMENT OF MELASMA. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 31(269 (SPECIAL ISSUE (SKIN DISEASES AND LEISHMANIASIS))), 2295-2300. SID. https://sid.ir/paper/50232/en

Vancouver: Copy

IRAJI FARIBA, ASILILAN ALI, FADAEI FATEMEH, NILFOROUSHZADEH MOHAMMAD ALI. COMPARING KOJIC ACID CREAM 2% WITH GLYCOLIC ACID 10% AND HYDROQUINONE CREAM 2% IN TREATMENT OF MELASMA. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2014;31(269 (SPECIAL ISSUE (SKIN DISEASES AND LEISHMANIASIS))):2295-2300. Available from: https://sid.ir/paper/50232/en

IEEE: Copy

FARIBA IRAJI, ALI ASILILAN, FATEMEH FADAEI, and MOHAMMAD ALI NILFOROUSHZADEH, “COMPARING KOJIC ACID CREAM 2% WITH GLYCOLIC ACID 10% AND HYDROQUINONE CREAM 2% IN TREATMENT OF MELASMA,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 31, no. 269 (SPECIAL ISSUE (SKIN DISEASES AND LEISHMANIASIS)), pp. 2295–2300, 2014, [Online]. Available: https://sid.ir/paper/50232/en

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