A CASE-CONTROL STUDY ON RISK FACTORS IN PEDIATRIC MULTIPLE SCLEROSIS POPULATION, ISFAHAN PROVINCE, IRAN: HIGHLIGHTING THE ROLE OF PUBERTY

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ETEMADIFAR MASOUD; MOEINI PEDRAM; MASOUMI SANAZ; BAGHERI GHALEHSALIMI AMIN; ALAVI ALI; FEREIDAN ESFAHANI MAHBOOBEH

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2017 | Volume:35 | Issue:424 Page(s): 335-339

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Title

A CASE-CONTROL STUDY ON RISK FACTORS IN PEDIATRIC MULTIPLE SCLEROSIS POPULATION, ISFAHAN PROVINCE, IRAN: HIGHLIGHTING THE ROLE OF PUBERTY

Author(s)

Keywords

MULTIPLE SCLEROSISQ1

EARLY-ONSETQ3

PEDIATRICQ2

RISK FACTORSQ3

PUBERTYQ3

CIGARETTE SMOKINGQ3

Abstract

Background: There is no a comprehensive study on EARLY-ONSET MULTIPLE SCLEROSIS (EOMS) population on the role of well-known MS RISK FACTORS. Moreover, age at PUBERTY and the critical window exposure to environmental RISK FACTORS is never investigated in neither adult nor PEDIATRIC MS population.Methods: A case-control study, including 97 patients with EARLY-ONSET MS and 97 matched controls, was conducted in Isfahan MULTIPLE SCLEROSIS Society. Information on age at PUBERTY, gestational RISK FACTORS, environmental exposures, and past medical history was obtained from medical charts and interviews.Findings: In logistic regression model, every year of decreasing in pubertal onset in females and males was associated with 1.766 and 2.250 folds increase in risk of EARLY-ONSET MS, respectively. In utero exposure to CIGARETTE SMOKING was significantly associated with 2.33 (P=0.010), and having smoker parents or passive smokers before PUBERTY had 2.88 (P=0.006) fold in risk of EARLY-ONSET MS. One hour less daily sun exposure increased the risk of EARLY-ONSET MS as 2.007 folds (P<0.001) after adjustment for age and sex.Conclusion: In utero and parental exposure to smoking as well as history of measles and appendectomy are RISK FACTORS for EARLY-ONSET MS. Future studies should shed more light on the true interaction between pineal gland, gender, smoking, sunlight and other environmental and genetic RISK FACTORS in adult and PEDIATRIC MS population.

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References

VITAMIN D: SHINING A LIGHT ON CLINICAL AND SEX SPECIFIC EFFECTS IN MULTIPLE SCLEROSIS?

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APA: Copy

ETEMADIFAR, MASOUD, MOEINI, PEDRAM, MASOUMI, SANAZ, BAGHERI GHALEHSALIMI, AMIN, ALAVI, ALI, & FEREIDAN ESFAHANI, MAHBOOBEH. (2017). A CASE-CONTROL STUDY ON RISK FACTORS IN PEDIATRIC MULTIPLE SCLEROSIS POPULATION, ISFAHAN PROVINCE, IRAN: HIGHLIGHTING THE ROLE OF PUBERTY. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 35(424), 335-339. SID. https://sid.ir/paper/50298/en

Vancouver: Copy

ETEMADIFAR MASOUD, MOEINI PEDRAM, MASOUMI SANAZ, BAGHERI GHALEHSALIMI AMIN, ALAVI ALI, FEREIDAN ESFAHANI MAHBOOBEH. A CASE-CONTROL STUDY ON RISK FACTORS IN PEDIATRIC MULTIPLE SCLEROSIS POPULATION, ISFAHAN PROVINCE, IRAN: HIGHLIGHTING THE ROLE OF PUBERTY. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2017;35(424):335-339. Available from: https://sid.ir/paper/50298/en

IEEE: Copy

MASOUD ETEMADIFAR, PEDRAM MOEINI, SANAZ MASOUMI, AMIN BAGHERI GHALEHSALIMI, ALI ALAVI, and MAHBOOBEH FEREIDAN ESFAHANI, “A CASE-CONTROL STUDY ON RISK FACTORS IN PEDIATRIC MULTIPLE SCLEROSIS POPULATION, ISFAHAN PROVINCE, IRAN: HIGHLIGHTING THE ROLE OF PUBERTY,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 35, no. 424, pp. 335–339, 2017, [Online]. Available: https://sid.ir/paper/50298/en

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