STUDY OF P53 POLYMORPHISM AT CODON 72 IN PATIENTS OF BREAST CANCER IN ISFAHAN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

FAGHANI M.; NIKBAKHT M.; SALEHI MANSOUR; RABANI M.; TALEBI A.; SOLEIMANI B.; FAGHIHI M.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2007 | Volume:25 | Issue:84 Page(s): 26-33

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,663

Download:

Cites:

Information Journal Paper

Title

STUDY OF P53 POLYMORPHISM AT CODON 72 IN PATIENTS OF BREAST CANCER IN ISFAHAN

Author(s)

Keywords

POLYMORPHISMQ2

P53 CODON 72Q3

BREAST CANCERQ2

Abstract

Background: The p53 tumor suppressor gene plays an important role in genomic stability. A common G-to-C POLYMORPHISM at codon 72 in the p53 gene has been accompanied with high risk of lung, nasopharyngeal, oral, prostate, and colorectal cancers, and may result in genetic susceptibility to BREAST CANCER. We studied the effect of this p53 POLYMORPHISM on breast invasive ductal carcinoma developmentMethods: This case–control study was conducted among 51 patients with breast invasive ductal carcinoma and 51 matched controls in Isfahan. P53 CODON 72 genotypes were identified using allele-specific polymerase chain reaction (PCR).Findings: In control samples, the genotype distribution of p53 POLYMORPHISM showed 43.2%, 52.9% and 3.9% for the Arg/Arg, Arg/Pro and Pro/Pro genotypes, respectively. In cancer group the distribution was 86.2% for Arg/Arg, 11.8% for Arg/Pro and 2% for Pro/Pro. Distribution differences in P53 CODON 72 POLYMORPHISM between the cases and controls were statistically significant (P<0.001).Conclusion: This study indicates that P53 CODON 72 POLYMORPHISM is a genetic predisposing factor for breast invasive ductal carcinoma development in samples of Isfahan. However, further studies are needed to determine the role of p53 codon72 POLYMORPHISM in BREAST CANCER development.

Cites

No record.

References

No record.

Cite

APA: Copy

FAGHANI, M., NIKBAKHT, M., SALEHI, MANSOUR, RABANI, M., TALEBI, A., SOLEIMANI, B., & FAGHIHI, M.. (2007). STUDY OF P53 POLYMORPHISM AT CODON 72 IN PATIENTS OF BREAST CANCER IN ISFAHAN. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 25(84), 26-33. SID. https://sid.ir/paper/50513/en

Vancouver: Copy

FAGHANI M., NIKBAKHT M., SALEHI MANSOUR, RABANI M., TALEBI A., SOLEIMANI B., FAGHIHI M.. STUDY OF P53 POLYMORPHISM AT CODON 72 IN PATIENTS OF BREAST CANCER IN ISFAHAN. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2007;25(84):26-33. Available from: https://sid.ir/paper/50513/en

IEEE: Copy

M. FAGHANI, M. NIKBAKHT, MANSOUR SALEHI, M. RABANI, A. TALEBI, B. SOLEIMANI, and M. FAGHIHI, “STUDY OF P53 POLYMORPHISM AT CODON 72 IN PATIENTS OF BREAST CANCER IN ISFAHAN,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 25, no. 84, pp. 26–33, 2007, [Online]. Available: https://sid.ir/paper/50513/en

Related Journal Papers