EFFECTS OF PROSOPIS FARCTA HYDRO-ALCOHOLIC SEED EXTRACT ON THIOACETAMIDE-INDUCED ACUTE LIVER TOXICITY IN RATS

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MOHAMMADPOUR ZEHAB MARYAM; SHARIATI SHARIFI FARIBORZ; JAMSHIDIAN ABBAS; HAJINEZHAD MOHAMMAD REZA

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2017 | Volume:35 | Issue:421 Page(s): 216-221

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Title

EFFECTS OF PROSOPIS FARCTA HYDRO-ALCOHOLIC SEED EXTRACT ON THIOACETAMIDE-INDUCED ACUTE LIVER TOXICITY IN RATS

Author(s)

MOHAMMADPOUR ZEHAB MARYAM | SHARIATI SHARIFI FARIBORZ | JAMSHIDIAN ABBAS | HAJINEZHAD MOHAMMAD REZA | Issue Writer Certificate

Keywords

THIOACETAMIDEQ1

LIVERQ2

PROSOPISQ1

RATSQ2

Abstract

Background: In this survey, the protective effect of PROSOPIS farcta seed hydro-alcoholic extract against acute hepatotoxicity induced by THIOACETAMIDE in rat was studied.Methods: 30 male RATS were equally divided to 3 groups. The first group received normal saline orally. The second and third group received thioacetamid (50 mg/kg intraperitoneally) three times at an interval of 24 hours.Rats in the third group received hydro-alcoholic extract of PROSOPIS fracta seed extract (100 mg/kg orally) for 3 weeks. Serum LIVER enzymes and malondialdehyde (MDA) levels were assayed. After tissue processing, histopathological changes of LIVER were examined under light microscopy. Data were compared using one-way ANOVA and Tukey tests at the significance level of P<0.050.Findings: Intraperitoneal injection of THIOACETAMIDE significantly increased LIVER enzymes in RATS (P<0.050).Oral administration of PROSOPIS farcta seed extract significantly decreased serum levels of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), and malondialdehyde compared with the negative control RATS (P<0.050). In addition, the histopathological investigations revealed that treatment with PROSOPIS farcta seed extract significantly decreased hepatic necrosis and degeneration in comparison to negative control group (P<0.050).Conclusion: These results showed the protective effect of PROSOPIS farcta hydro-alcoholic extract on acute LIVER injury in RATS.

Cites

Evaluating the effect of curcumin on Thioacetamide-induced liver in maturemale rats

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APA: Copy

MOHAMMADPOUR ZEHAB, MARYAM, SHARIATI SHARIFI, FARIBORZ, JAMSHIDIAN, ABBAS, & HAJINEZHAD, MOHAMMAD REZA. (2017). EFFECTS OF PROSOPIS FARCTA HYDRO-ALCOHOLIC SEED EXTRACT ON THIOACETAMIDE-INDUCED ACUTE LIVER TOXICITY IN RATS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 35(421), 216-221. SID. https://sid.ir/paper/50523/en

Vancouver: Copy

MOHAMMADPOUR ZEHAB MARYAM, SHARIATI SHARIFI FARIBORZ, JAMSHIDIAN ABBAS, HAJINEZHAD MOHAMMAD REZA. EFFECTS OF PROSOPIS FARCTA HYDRO-ALCOHOLIC SEED EXTRACT ON THIOACETAMIDE-INDUCED ACUTE LIVER TOXICITY IN RATS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2017;35(421):216-221. Available from: https://sid.ir/paper/50523/en

IEEE: Copy

MARYAM MOHAMMADPOUR ZEHAB, FARIBORZ SHARIATI SHARIFI, ABBAS JAMSHIDIAN, and MOHAMMAD REZA HAJINEZHAD, “EFFECTS OF PROSOPIS FARCTA HYDRO-ALCOHOLIC SEED EXTRACT ON THIOACETAMIDE-INDUCED ACUTE LIVER TOXICITY IN RATS,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 35, no. 421, pp. 216–221, 2017, [Online]. Available: https://sid.ir/paper/50523/en

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