THE EFFECT OF THALIDOMIDE ON BLEOMYCIN-INDUCED PULMONARY FIBROSIS IN RATS

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RAFIEIAN SH.; ALAVI SEYED ALI; MIRKHESHTI NOUSHIN; SADEGHIZADEH A.

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Journal: Journal of Isfahan Medical School Year:2009 | Volume:27 | Issue:97 Page(s): 374-379

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Information Journal Paper

Title

THE EFFECT OF THALIDOMIDE ON BLEOMYCIN-INDUCED PULMONARY FIBROSIS IN RATS

Author(s)

RAFIEIAN SH. | ALAVI SEYED ALI | MIRKHESHTI NOUSHIN | SADEGHIZADEH A. | Issue Writer Certificate

Keywords

PULMONARY FIBROSISQ2

THALIDOMIDEQ2

BLEOMYCINQ3

ANGIOGENESISQ2

Abstract

Background: Current evidences suggest that the change in cytokine level by induction of ANGIOGENESIS may play a key role in the development of lung fibrosis. It seems, THALIDOMIDE by the destruction of endothelial cells and changing TNF-a level could be help full in antiangiogenic therapies. The present study examined the effect of THALIDOMIDE on BLEOMYCIN-induced lung fibrosis in rats.Methods: 18 rats were divided into three groups: (group 1) negative control group, which received normal saline intratracheally, (group 2) positive control group in which BLEOMYCIN was intratracheally injected, (3) intervention group which recieved THALIDOMIDE and BLEOMYCINe.Findings: Lung tissue was extracted after one month of treatment. Collagen content (as fibrosis index) and ANGIOGENESIS were indicated by Woessner method and Von Wilbrand staining, respectively. Total Lung Capacity index, was determined by MATLAB software.Collagen content had significant difference between positive and negative control groups, but there was no difference between positive control and experimental group. There was no significant difference between groups for ANGIOGENESIS and Total Lung Capacity index. Thalidomide had no effect on BLEOMYCIN induced PULMONARY FIBROSIS.Conclusion: Otherwise, the findings of the study provide this evidence that THALIDOMIDE may induce pulmonary injury that is pathologically looks like IPF. So, more studies with some other angiostatic drugs and different doses are needed.

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APA: Copy

RAFIEIAN, SH., ALAVI, SEYED ALI, MIRKHESHTI, NOUSHIN, & SADEGHIZADEH, A.. (2009). THE EFFECT OF THALIDOMIDE ON BLEOMYCIN-INDUCED PULMONARY FIBROSIS IN RATS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 27(97), 374-379. SID. https://sid.ir/paper/50567/en

Vancouver: Copy

RAFIEIAN SH., ALAVI SEYED ALI, MIRKHESHTI NOUSHIN, SADEGHIZADEH A.. THE EFFECT OF THALIDOMIDE ON BLEOMYCIN-INDUCED PULMONARY FIBROSIS IN RATS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2009;27(97):374-379. Available from: https://sid.ir/paper/50567/en

IEEE: Copy

SH. RAFIEIAN, SEYED ALI ALAVI, NOUSHIN MIRKHESHTI, and A. SADEGHIZADEH, “THE EFFECT OF THALIDOMIDE ON BLEOMYCIN-INDUCED PULMONARY FIBROSIS IN RATS,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 27, no. 97, pp. 374–379, 2009, [Online]. Available: https://sid.ir/paper/50567/en

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