THE EFFECT OF COCAINE AND SEROTONERGIC ANTAGONIST (CYPROHEPTADINE) ON INFLAMMATORY PAW EDEMA IN RAT

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MAHDINIYA RAHEBEH; FEREIDONI MASOUD; MOGHIMI ALI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Isfahan Medical School Year:2013 | Volume:31 | Issue:257 Page(s): 1703-1712

Download Full-Text

Persian Verion

View:

2,329

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF COCAINE AND SEROTONERGIC ANTAGONIST (CYPROHEPTADINE) ON INFLAMMATORY PAW EDEMA IN RAT

Author(s)

MAHDINIYA RAHEBEH | FEREIDONI MASOUD | MOGHIMI ALI | Issue Writer Certificate

Keywords

COCAINEQ2

INFLAMMATIONQ2

SEROTONINQ2

CYPROHEPTADINEQ3

Abstract

Background: COCAINE is a central nervous system stimulant and is an inhibitor of monoamine (serotonin, norepinephrine and dopamine) reuptake; so increases their concentration in central nervous system. Monoamines such as SEROTONIN and nor epinephrine have a role in anti-inflammatory effects and in modulating of immune system. The aim of this study was to investigate the effect of systemic and spinal administration of COCAINE (none selective inhibitor of monoamine reuptake) on inflammatory paw edema and the role of SEROTONIN neurotransmitter in these effects at the spinal level.Methods: 56 Male Wistar rats (200-250 g) were set in 8 groups: Intraperitoneal Saline, Intraperitoneal Saline/Dimethyl sulfoxide (DMSO), Intraperitoneal COCAINE 25 mg/kg, Intrathecal Saline, Intrathecal Saline/DMSO, Intrathecal COCAINE 100 mg/10 ml, Intrathecal CYPROHEPTADINE 33 mg/10 ml and Intrathecal CYPROHEPTADINE 33 mg/10 ml/COCAINE 100 mg/10 ml. INFLAMMATION was induced by subplantar injection of formalin.Findings: Anti-inflammatory effects of COCAINE was significant in intraperitoneal COCAINE 25 mg/kg (P<0.001) and intrathecal COCAINE 100 mg/10 ml (P<0.001) groups. In intrathecal CYPROHEPTADINE 33 mg/10 ml group, there was no influence on INFLAMMATION. In intrathecal CYPROHEPTADINE 33 mg/10ml/COCAINE 100 mg/10 ml, CYPROHEPTADINE decreased a part of anti-inflammatory effect of COCAINE (P<0.001).Conclusion: Serotonergic terminals coming from higher center to the spinal cord interacts with spinal neurons such as primary afferent C fibers. Probably, the inhibition of primary afferent fibers by SEROTONIN inhibits release of inflammatory agent from these fibers and causes anti-inflammatory effects. It is likely that inhibition of SEROTONIN receptor at the spinal level by intrathecal administration of CYPROHEPTADINE has reduced anti-inflammatory effects of COCAINE.

Cites

No record.

References

No record.

Cite

APA: Copy

MAHDINIYA, RAHEBEH, FEREIDONI, MASOUD, & MOGHIMI, ALI. (2013). THE EFFECT OF COCAINE AND SEROTONERGIC ANTAGONIST (CYPROHEPTADINE) ON INFLAMMATORY PAW EDEMA IN RAT. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 31(257), 1703-1712. SID. https://sid.ir/paper/50775/en

Vancouver: Copy

MAHDINIYA RAHEBEH, FEREIDONI MASOUD, MOGHIMI ALI. THE EFFECT OF COCAINE AND SEROTONERGIC ANTAGONIST (CYPROHEPTADINE) ON INFLAMMATORY PAW EDEMA IN RAT. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2013;31(257):1703-1712. Available from: https://sid.ir/paper/50775/en

IEEE: Copy

RAHEBEH MAHDINIYA, MASOUD FEREIDONI, and ALI MOGHIMI, “THE EFFECT OF COCAINE AND SEROTONERGIC ANTAGONIST (CYPROHEPTADINE) ON INFLAMMATORY PAW EDEMA IN RAT,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 31, no. 257, pp. 1703–1712, 2013, [Online]. Available: https://sid.ir/paper/50775/en

Related Journal Papers