MOLECULAR TYPING OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS STRAINS ISOLATED FROM PATIENTS ADMITTED TO INTENSIVE CARE UNITS OF HOSPITALS IN TEHRAN CITY, IRAN, BASED ON AGR PATTERN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NASIRIAN SARA; SAADATMAND SARA; GOUDARZI MEHDI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2017 | Volume:35 | Issue:451 Page(s): 1424-1431

Download Full-Text

Persian Verion

View:

617

Download:

Cites:

Information Journal Paper

Title

MOLECULAR TYPING OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS STRAINS ISOLATED FROM PATIENTS ADMITTED TO INTENSIVE CARE UNITS OF HOSPITALS IN TEHRAN CITY, IRAN, BASED ON AGR PATTERN

Author(s)

NASIRIAN SARA | SAADATMAND SARA | GOUDARZI MEHDI | Issue Writer Certificate

Keywords

STAPHYLOCOCCUS AUREUSQ1

METHICILLIN RESISTANCEQ2

MOLECULAR TYPINGQ1

Abstract

Background: STAPHYLOCOCCUS AUREUS is one of the most commonly diagnosed infections in hospitals. Increased infections caused by this bacterium and its resistance to many antibiotics is leading to increasing morbidity and mortality in the hospital setting. The aim of this study was to investigate the molecular status of methicillinresistant STAPHYLOCOCCUS AUREUS (MRSA) isolated from patients admitted to intensive care units (ICUs) of hospitals in Tehran City, Iran.Methods: This cross-sectional study was performed by analyzing 125 MRSA strains isolated from hospitalized patients in ICUs. In vitro antibiotic susceptibility testing of isolates was assessed using Kirby-Bauer disk diffusion method. MRSA strains were genetically typed by agr typing and virulence and adhesion genes profile via conventional polymerase chain reaction (PCR) method.Findings: Of 443 clinical studied samples, 125 MRSA strains were observed. The highest resistance rates were observed for penicillin antibodies (122, 97.6%), kanamycin (105, 84.0%), and gentamicin (95, 76.0%). Frequency of pvl and tst genes was 67.2% and 20%, respectively. Type I was the most prevalent agr type (52.0%), followed by type III (34.4%), type II (9.6%), type I 5(5.3%), and type IV (4%). All the isolates carrying Panton-Valentine leukocidin (PVL)-encoding genes and high-level mupirocin-resistance (HLMUPR)-MRSA strains corresponded exclusively to agr type I.Conclusion: This study demonstrates the increased resistance of STAPHYLOCOCCUS AUREUS to different antibiotics, which is a serious warning for the treatment of STAPHYLOCOCCUS AUREUS infection in the region. Therefore, in order to avoid resistance to other antibiotics, uncontrolled and unnecessary administration of antibiotics should be avoided.

Cites

No record.

References

No record.

Cite

APA: Copy

NASIRIAN, SARA, SAADATMAND, SARA, & GOUDARZI, MEHDI. (2017). MOLECULAR TYPING OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS STRAINS ISOLATED FROM PATIENTS ADMITTED TO INTENSIVE CARE UNITS OF HOSPITALS IN TEHRAN CITY, IRAN, BASED ON AGR PATTERN. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 35(451 ), 1424-1431. SID. https://sid.ir/paper/50829/en

Vancouver: Copy

NASIRIAN SARA, SAADATMAND SARA, GOUDARZI MEHDI. MOLECULAR TYPING OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS STRAINS ISOLATED FROM PATIENTS ADMITTED TO INTENSIVE CARE UNITS OF HOSPITALS IN TEHRAN CITY, IRAN, BASED ON AGR PATTERN. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2017;35(451 ):1424-1431. Available from: https://sid.ir/paper/50829/en

IEEE: Copy

SARA NASIRIAN, SARA SAADATMAND, and MEHDI GOUDARZI, “MOLECULAR TYPING OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS STRAINS ISOLATED FROM PATIENTS ADMITTED TO INTENSIVE CARE UNITS OF HOSPITALS IN TEHRAN CITY, IRAN, BASED ON AGR PATTERN,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 35, no. 451 , pp. 1424–1431, 2017, [Online]. Available: https://sid.ir/paper/50829/en

Related Journal Papers