THE INTERACTION OF INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3 (IGFBP-3) IN INSULIN-LIKE GROWTH FACTOR (IGF)-INDEPENDENT SYSTEM

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ANSARI AMIR; GHEYSARZADEH ALI; MOFID MOHAMMAD REZA

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2017 | Volume:35 | Issue:451 Page(s): 1452-1461

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

866

Download:

Cites:

Information Journal Paper

Title

THE INTERACTION OF INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3 (IGFBP-3) IN INSULIN-LIKE GROWTH FACTOR (IGF)-INDEPENDENT SYSTEM

Author(s)

ANSARI AMIR | GHEYSARZADEH ALI | MOFID MOHAMMAD REZA | Issue Writer Certificate

Keywords

INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3Q1

APOPTOSISQ1

CANCERQ2

Abstract

Insulin-like growth factor-binding protein 3 (IGFBP-3) is the most abundant IGFBP in circulation, interacts with high affinity to IGFs altering their function. Emerging evidence has indicated that IGFBP3 mostly involved in human disease such as diabetes, Alzheimer's disease, and CANCER. It has been determined that IGFBP3 expression is decreased in various CANCER cell lines by promoter methylation and proteases digestion. Therefore, bioavailable form of IGF-I increases in circulation promoting the tumorigenesis and progression of CANCER. IGFBP3 function in CANCER suppressing can be divided in two ways: IGF-dependent, and IGF-independent action. Recently it has been shown that IGFBP3 has vital roles independent of IGFs. Despite decades of unremitting research, this function of IGFBP-3 has not been clarified. However, it has been suggested that IGFBP3 independently can bind to its receptors in the nucleus including retinoid receptors (RXRs) peroxisome proliferator activated receptors (PPARg), Nur77 vitamin D response (VDR), and/or cell surface receptors such as transmembrane protein 219 (TMEM219), low-density lipoprotein receptor-related protein 1 (LRP-1), and epidermal growth factor receptor (EGFR) inducing APOPTOSIS. In this review, we described further mechanisms of IGF-independent action of IGFBP3.

Cites

No record.

References

No record.

Cite

APA: Copy

ANSARI, AMIR, GHEYSARZADEH, ALI, & MOFID, MOHAMMAD REZA. (2017). THE INTERACTION OF INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3 (IGFBP-3) IN INSULIN-LIKE GROWTH FACTOR (IGF)-INDEPENDENT SYSTEM. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 35(451 ), 1452-1461. SID. https://sid.ir/paper/50834/en

Vancouver: Copy

ANSARI AMIR, GHEYSARZADEH ALI, MOFID MOHAMMAD REZA. THE INTERACTION OF INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3 (IGFBP-3) IN INSULIN-LIKE GROWTH FACTOR (IGF)-INDEPENDENT SYSTEM. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2017;35(451 ):1452-1461. Available from: https://sid.ir/paper/50834/en

IEEE: Copy

AMIR ANSARI, ALI GHEYSARZADEH, and MOHAMMAD REZA MOFID, “THE INTERACTION OF INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3 (IGFBP-3) IN INSULIN-LIKE GROWTH FACTOR (IGF)-INDEPENDENT SYSTEM,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 35, no. 451 , pp. 1452–1461, 2017, [Online]. Available: https://sid.ir/paper/50834/en

Related Journal Papers