THE PROGNOSTIC SIGNIFICANCE OF TUMOR ANGIOGENESIS IN BASAL CELL CARCINOMA OF HUMAN SKIN

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RAJABI P.; MOLAEI M.M.; ASILIAN A.

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2003 | Volume:21 | Issue:68 Page(s): 1-4

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Title

THE PROGNOSTIC SIGNIFICANCE OF TUMOR ANGIOGENESIS IN BASAL CELL CARCINOMA OF HUMAN SKIN

Author(s)

RAJABI P. | MOLAEI M.M. | ASILIAN A. | Issue Writer Certificate

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Abstract

Introduction. Basal cell carcinoma (BCC) is the most commonly cutaneous cancer found in human. Althoughit generally shows a relativelybenign course (BCC1), some cases show aggressive behavior (BCC2). Until now the traditional histologic diagnostic criteria have failed to discriminateunequivocallybetweenBCC1and BCC2.Methods. In this study we selected 56 cases of BCC and categorized them into two equal groups (BCC1 and BCC2) on the basis of histologic criteria and then examined the rate of angiogenesis to establish if it correlates with their histologic features and/or clinical behavior. The vessels were highlighted by immunohistochemical staining for factor VIII related antigen in formalin fixed paraffin embedded tissues.Results. All of 28 cases of BCC2, whose clinical behavior was aggressive had microvessel count significantly higher than that of BCC1 cases with the mean values of 52.8 and 21.1 for BCC2 and BCC1, respectively. But there were eight cases of morphologically BCC1 who had aggressive clinical behavior and interestingly microvesscl count higher than the other BCC1 cases.Discussion. The findings of the present study seem to establish correlation between tumor angiogenesis and clinicobiological parameters of aggressiveness. From this point of view the assay of microvessel density might be helpful in selecting patients with BCCs at high risk for recurrence or metastasis who could benefit from additional therapies and closer follow up.

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APA: Copy

RAJABI, P., MOLAEI, M.M., & ASILIAN, A.. (2003). THE PROGNOSTIC SIGNIFICANCE OF TUMOR ANGIOGENESIS IN BASAL CELL CARCINOMA OF HUMAN SKIN. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 21(68), 1-4. SID. https://sid.ir/paper/50900/en

Vancouver: Copy

RAJABI P., MOLAEI M.M., ASILIAN A.. THE PROGNOSTIC SIGNIFICANCE OF TUMOR ANGIOGENESIS IN BASAL CELL CARCINOMA OF HUMAN SKIN. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2003;21(68):1-4. Available from: https://sid.ir/paper/50900/en

IEEE: Copy

P. RAJABI, M.M. MOLAEI, and A. ASILIAN, “THE PROGNOSTIC SIGNIFICANCE OF TUMOR ANGIOGENESIS IN BASAL CELL CARCINOMA OF HUMAN SKIN,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 21, no. 68, pp. 1–4, 2003, [Online]. Available: https://sid.ir/paper/50900/en

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