ELECTRON MICROSCOPIC STUDY OF EFFECT OF LEAD ON MORPHOLOGICAL CHANGES IN ENDOTHELIAL CELLS OF AORTA, CORNARY AND MIDDLE CEREBRAL ARTERIES IN RABBITS

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DASHTI G.R.; NEMATBAKHSH M.; MARDANI M.; HAMI J.; SABERALI S.M.

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2004 | Volume:22 | Issue:73 Page(s): 27-30

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Title

ELECTRON MICROSCOPIC STUDY OF EFFECT OF LEAD ON MORPHOLOGICAL CHANGES IN ENDOTHELIAL CELLS OF AORTA, CORNARY AND MIDDLE CEREBRAL ARTERIES IN RABBITS

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Abstract

Introduction. The lumen of the vascular system is covered by a continuous layer of endothelial cells, and any changes or damages to them is due to cardiovascular diseases especially atherosclerosis. Lead is one of the elements which may cause endothelial dysfunction. The purpose of this study was to determine the effect of lead on morphologic features of endothelium which may induce the endothelial dysfunction.Methods. Twenty white male rabbits divided randomly into two groups. Group A (n=11) were given regular diet with leaded water (547 ppm) and group B (n=9) were fed with regular diet and unlead water for 40 days. The animals were sacrificed and their aorta, left cornorary and middle cerebral arteries were dissected and morphological changes of endothelial cells studied by SEM.Results. Scanning electron microscopic study of endothelial cells of aorta, left coronary and middle cerebral arteries that received lead showed morphological changes. In aorta disruption and denuation of endothelial cells, exposure of the subendothelial layer and adhesion of red blood cells, leukocytes and platelets on surface of endothelium, and presence of craters showing disrupted surface was observed. Similary endothelial cells of left coronary and middle cerebral arteries were found to show irregular orientation.Discussion. Morphologic changes of endothelial cells of aorta demonstrated that lead can cause dysfunction. In coronary and middle cerebral arteries very limited morphological changes was observed.

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References

THE EFFECT OF LEAD ON ENDOTHELIAL PERMEABILITY OF AORTA

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APA: Copy

DASHTI, G.R., NEMATBAKHSH, M., MARDANI, M., HAMI, J., & SABERALI, S.M.. (2004). ELECTRON MICROSCOPIC STUDY OF EFFECT OF LEAD ON MORPHOLOGICAL CHANGES IN ENDOTHELIAL CELLS OF AORTA, CORNARY AND MIDDLE CEREBRAL ARTERIES IN RABBITS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 22(73), 27-30. SID. https://sid.ir/paper/50982/en

Vancouver: Copy

DASHTI G.R., NEMATBAKHSH M., MARDANI M., HAMI J., SABERALI S.M.. ELECTRON MICROSCOPIC STUDY OF EFFECT OF LEAD ON MORPHOLOGICAL CHANGES IN ENDOTHELIAL CELLS OF AORTA, CORNARY AND MIDDLE CEREBRAL ARTERIES IN RABBITS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2004;22(73):27-30. Available from: https://sid.ir/paper/50982/en

IEEE: Copy

G.R. DASHTI, M. NEMATBAKHSH, M. MARDANI, J. HAMI, and S.M. SABERALI, “ELECTRON MICROSCOPIC STUDY OF EFFECT OF LEAD ON MORPHOLOGICAL CHANGES IN ENDOTHELIAL CELLS OF AORTA, CORNARY AND MIDDLE CEREBRAL ARTERIES IN RABBITS,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 22, no. 73, pp. 27–30, 2004, [Online]. Available: https://sid.ir/paper/50982/en

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