THE FREQUENCY OF BLAIMP AND BLAVIM CARBAPENEMASE GENES IN CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA IN ISFAHAN MEDICAL CENTERS

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RAHIMZADEH TORABI LADAN; DOUDI MONIREH; GOLSHANI ZEYNAB

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Journal: MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES Year:2016 | Volume:59 | Issue:3 Page(s): 139-147

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Title

THE FREQUENCY OF BLAIMP AND BLAVIM CARBAPENEMASE GENES IN CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA IN ISFAHAN MEDICAL CENTERS

Author(s)

RAHIMZADEH TORABI LADAN | DOUDI MONIREH | GOLSHANI ZEYNAB | Issue Writer Certificate

Keywords

ANTIBIOTIC RESISTANCEQ2

CARBAPENMASE GENESQ2

PSEUDOMONAS AERUGINOSAQ2

PCRQ2

Abstract

Introduction: This study aimed to investigate the discovery of ANTIBIOTIC RESISTANCE in isolates of PSEUDOMONAS AERUGINOSA and antibiotic susceptibility patterns and also, identify the gene encoding beta-lactamase in the isolated strains, isolated from nosocomial infections in patients admitted to the hospitals of Isfahan province.Methods: In this cross-sectional study, 51 isolates of PSEUDOMONAS AERUGINOSA were collected from patients in various hospitals and clinical laboratories in North, South and Central Isfahan. Then, antibiotic susceptibility of isolates was determined, using standard methods and disk diffusion method. The carbapenemase genes of blaVIM and blaIMP were detected by PCR test.Results: Clinical isolates of PSEUDOMONAS AERUGINOSA were most resistant to ciprofloxacin (96.08%), carbenicillin (92.16%), imipenem (80%), ampicillin (72.55%) and nitrofurantoin (78.43%), respectively. On the other hand, among the highest rates of infection by PSEUDOMONAS AERUGINOSA were wounds, by the rate of 33.33%. Of 51 cases with drug resistance, 32 strains (63%) had beta-lactamase-producing bla IMP gene, while none of the gene were blaVIM.Conclusion: The results of this study showed that resistance to antibiotics among strains of PSEUDOMONAS AERUGINOSA isolated from patients, were prevalent. Therefore, fast and precise evaluation of ANTIBIOTIC RESISTANCE is necessary, because the strains producing beta-lactamase, among hospital strains are on the rise.

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APA: Copy

RAHIMZADEH TORABI, LADAN, DOUDI, MONIREH, & GOLSHANI, ZEYNAB. (2016). THE FREQUENCY OF BLAIMP AND BLAVIM CARBAPENEMASE GENES IN CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA IN ISFAHAN MEDICAL CENTERS. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 59(3), 139-147. SID. https://sid.ir/paper/51368/en

Vancouver: Copy

RAHIMZADEH TORABI LADAN, DOUDI MONIREH, GOLSHANI ZEYNAB. THE FREQUENCY OF BLAIMP AND BLAVIM CARBAPENEMASE GENES IN CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA IN ISFAHAN MEDICAL CENTERS. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;59(3):139-147. Available from: https://sid.ir/paper/51368/en

IEEE: Copy

LADAN RAHIMZADEH TORABI, MONIREH DOUDI, and ZEYNAB GOLSHANI, “THE FREQUENCY OF BLAIMP AND BLAVIM CARBAPENEMASE GENES IN CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA IN ISFAHAN MEDICAL CENTERS,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 59, no. 3, pp. 139–147, 2016, [Online]. Available: https://sid.ir/paper/51368/en

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