EVALUATION OF CELLS WITH CD14 MARKER MONOCYTES IN PATIENTS WITH CUTANEOUS LEISHMANIASIS BEFORE AND AFTER MEDICAL TREATMENT

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MOHAJERI M.; SHAMSIAN S.A.A.; BIDKHORI H.R.; MAHMOUDI M.

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Paper Information

Journal: Medical Journal of Mashhad University of Medical Sciences Year:2006 | Volume:49 | Issue:93 Page(s): 241-246

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Title

EVALUATION OF CELLS WITH CD14 MARKER MONOCYTES IN PATIENTS WITH CUTANEOUS LEISHMANIASIS BEFORE AND AFTER MEDICAL TREATMENT

Author(s)

MOHAJERI M. | SHAMSIAN S.A.A. | BIDKHORI H.R. | MAHMOUDI M. | Issue Writer Certificate

Keywords

LEISHMANIASISQ3

MONOCYTESQ3

CD14 MARKERQ3

FLOW CYTOMETRYQ3

Abstract

Introduction: LEISHMANIASIS is one of the human diseases severity of witch varies from a self limiting cutaneous lesion to a severe visceral form. It is endemic in several parts of the world including our country Iran and especially in the province of Khorasan and the city of Mashhad. The study was intended to evaluate the percentage of monocellular macrophages in 36 patients and to investigate their role in prevention of the disease and its response to the treatment.Material and Methods: The study was a case-control study conducted from August 2001 until October 2002 in Ghaem Hospital and Bu-Ali Research Ins. of Mashhad University of Medical Sciences and fmally 29 patients were carried out the survey as the study group and 23 people of their families as control group.A blood sample of 10 cc was obtained from both groups before and after treatment. Compelet Blood Counting and CD14 marker studies by flow cytometry for evaluating monocyte percentage were used. Personal, laboratory and treatment data were recorded in a question are. Qualitive and descriptive statistics were used for analysis.Results: The percentage of MONOCYTES in the whole population of patients was significantly more than control group (p=0.006).The percentage of MONOCYTES in patients who gave a positive response to the treatment (group 1) and those who did not recovered after the treatment (group 2) was significantly higher, with a p value of 0.013 and 0.015 respectively ,comparing with the control group. In order to get a more delicate evaluation, the study was repeated again by flow cytometry method considering the CD14 marker. The result was similar; percentage of CD14 was increased. significantly in whole patients, first group and second group (p<0.001, p= 0.003 and p=0.015 respectively), comparing with the control group. Meanwhile, comparing the "threestudied groups before and after medical treatment, the percentage of MONOCYTES slightly decreased; the study had a similar result conducted for evaluating CD14 marker.Conclusion: This study suggests the major role of MONOCYTES in revealing the disease and perhaps decreased percentage of MONOCYTES caused by the influence of medical treatment.

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APA: Copy

MOHAJERI, M., SHAMSIAN, S.A.A., BIDKHORI, H.R., & MAHMOUDI, M.. (2006). EVALUATION OF CELLS WITH CD₁₄ MARKER MONOCYTES IN PATIENTS WITH CUTANEOUS LEISHMANIASIS BEFORE AND AFTER MEDICAL TREATMENT . MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 49(93), 241-246. SID. https://sid.ir/paper/51631/en

Vancouver: Copy

MOHAJERI M., SHAMSIAN S.A.A., BIDKHORI H.R., MAHMOUDI M.. EVALUATION OF CELLS WITH CD₁₄ MARKER MONOCYTES IN PATIENTS WITH CUTANEOUS LEISHMANIASIS BEFORE AND AFTER MEDICAL TREATMENT . MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;49(93):241-246. Available from: https://sid.ir/paper/51631/en

IEEE: Copy

M. MOHAJERI, S.A.A. SHAMSIAN, H.R. BIDKHORI, and M. MAHMOUDI, “EVALUATION OF CELLS WITH CD₁₄ MARKER MONOCYTES IN PATIENTS WITH CUTANEOUS LEISHMANIASIS BEFORE AND AFTER MEDICAL TREATMENT ,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 49, no. 93, pp. 241–246, 2006, [Online]. Available: https://sid.ir/paper/51631/en

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