EFFICACY OF ADDITION OF FOLIC ACID TO SODIUM VALPROATE IN TREATMENT OF ACUTE MANIA, A DOUBLE BLIND CLINICAL TRIAL STUDY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

EBRAHIMI ALIREZA; TALAEI ALI; MOKHBER NAGHMEH; AKBARZADEH FARZAD; AKHLAGHI SAEED; NEJATI RAHELEH; TALAEI ANDISHEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Medical Journal of Mashhad University of Medical Sciences Year:2014 | Volume:57 | Issue:1 Page(s): 398-405

Download Full-Text

Persian Verion

View:

1,537

Download:

Cites:

Information Journal Paper

Title

EFFICACY OF ADDITION OF FOLIC ACID TO SODIUM VALPROATE IN TREATMENT OF ACUTE MANIA, A DOUBLE BLIND CLINICAL TRIAL STUDY

Author(s)

Keywords

BIPOLAR MOOD DISORDERQ2

FOLIC ACIDQ3

MANIAQ2

SODIUM VALPROATEQ2

Abstract

Introduction: Treatment resistance is common in acute MANIA, so the role of augmented therapies, including nutritional factors and vitamins have always been considered. This study aimed to assess the effect of addition of FOLIC ACID to SODIUM VALPROATE in treatment of acute MANIA.Methods: This double blind randomized clinical trial study was done in Mashhad Avicenna psychiatric hospital, in 2011 and was registered with IRCT201112188106N1 code in Iranian registry clinical trials site.Twenty nine manic patients, divided into two groups randomly. They received sodium-valproate+folic acid or sodium-valproate+placebo.The severity of MANIA, by Jung MANIA Rating Scale (YMRS), and cognitional improvement, by Mini-Mental State Examination (MMSE), were determined at baseline, after 3 and 6 weeks. Data analyzed by SPSS-16, к2 and t-student tests.Result: The mean scores of YMRS at baseline, after 3 and 6 weeks, in the folice acid group were 22±2.44, 8.26±4.86 and 3.13±1.64 respectively, and in placebo group were 21.14±1.95, 14.14±4.31 and 13±5.21 respectively. The mean scores of YMRS significantly decreased in the FOLIC ACID group compared to the placebo group after 3, 6 weeks (p=0.005, p<0.001 respectively). The mean scores of MMSE showed no significant difference in same intervals (p=0.068, p=0.068).Conclusion: Our study showed that adjuvant treatment by FOLIC ACID in addition to standard treatment with sodium-valproate during manic phase in patients with BMD-I after 6 weeks of treatment was effective.

Cites

COMPARISON OF THE EFFICACY OF RISPERIDONE AND ARIPIPRAZOLE IN COMBINATION WITH SODIUM VALPROATE IN PATIENTS WITH ACUTE MANIC OR MIXED EPISODES

References

No record.

Cite

APA: Copy

EBRAHIMI, ALIREZA, TALAEI, ALI, MOKHBER, NAGHMEH, AKBARZADEH, FARZAD, AKHLAGHI, SAEED, NEJATI, RAHELEH, & TALAEI, ANDISHEH. (2014). EFFICACY OF ADDITION OF FOLIC ACID TO SODIUM VALPROATE IN TREATMENT OF ACUTE MANIA, A DOUBLE BLIND CLINICAL TRIAL STUDY. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 57(1), 398-405. SID. https://sid.ir/paper/51956/en

Vancouver: Copy

EBRAHIMI ALIREZA, TALAEI ALI, MOKHBER NAGHMEH, AKBARZADEH FARZAD, AKHLAGHI SAEED, NEJATI RAHELEH, TALAEI ANDISHEH. EFFICACY OF ADDITION OF FOLIC ACID TO SODIUM VALPROATE IN TREATMENT OF ACUTE MANIA, A DOUBLE BLIND CLINICAL TRIAL STUDY. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;57(1):398-405. Available from: https://sid.ir/paper/51956/en

IEEE: Copy

ALIREZA EBRAHIMI, ALI TALAEI, NAGHMEH MOKHBER, FARZAD AKBARZADEH, SAEED AKHLAGHI, RAHELEH NEJATI, and ANDISHEH TALAEI, “EFFICACY OF ADDITION OF FOLIC ACID TO SODIUM VALPROATE IN TREATMENT OF ACUTE MANIA, A DOUBLE BLIND CLINICAL TRIAL STUDY,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 57, no. 1, pp. 398–405, 2014, [Online]. Available: https://sid.ir/paper/51956/en

Related Journal Papers