CIPROFLOXACIN VS. METRONIDAZOLE IN QUADRUPLE THERAPY REGIMENS FOR THE TREATMENT OF H .PYLORI INFECTION IN PATIENTS WITH DUODENAL ULCER

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VOSOUGHINIA H.

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Paper Information

Journal: MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES Year:2003 | Volume:46 | Issue:79 Page(s): 21-26

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Title

CIPROFLOXACIN VS. METRONIDAZOLE IN QUADRUPLE THERAPY REGIMENS FOR THE TREATMENT OF H .PYLORI INFECTION IN PATIENTS WITH DUODENAL ULCER

Author(s)

VOSOUGHINIA H. | | | Issue Writer Certificate

Keywords

HELICOBACTER PYLORIQ3

CIPROFLOXACINQ3

METRONIDAZOLEQ3

QUADRUPLE THERAPYQ4

DUODENALQ4

Abstract

HELICOBACTER PYLORI infection is an important risk factor for peptic ulcer disease and eradication of H. pylori infection decrease the complication and recurrence of peptic ulcer disease.To determine the efficacy and safety of CIPROFLOXACIN in bismuth based quadruple regimens in eradication of H. pylori infection. Eighty-five patients with DUODENAL ulcer and H. pylori infection that were confirmed by endoscopy and rapid urease test completed this study in Ghaem hospital of Mashad University of Medical Sciences - Iran. The patients were randomly divided in two groups A and B. Patients in group A received METRONIDAZOLE 2x500 mg. + omeprazole 2x20 mg. + bismuth s.c. 2x240 mg. + amoxicilin 2x1 gr. for 2 weeks and group B receivedciprofloxacin2x500 mg. + omeprazole2x20 mg. + bismuth S.C.2x240 mg. + amoxicilin2xl gr. for2 weeks. Both groups received ranitidine 150 mg twice daily for another 30 days. At least one week after completion of therapy urea breath test (UBT)is performed for assessment of eradication. Statistical analysis was performed by SPSS software. Chi-square tests and T-test groups and X2 were used to compare the eradication rates. The patients underwent a second line regimens therapy (cross treatment) only if they had a positive UBT.All patients tolerated the medications. The mean age in-group A and B were 45.42 and 42.93 years respectively. Eradication rate of H. pylori infection were 76.7% and 73.8% in-groups A and B respectively (p = 0.75). Only 11 out of 21 patients who failed H. pylori eradication switched to second line therapy (cross treatment) and H. pylori eradicate were achieved in 3 of 3 patients in METRONIDAZOLE group and 3 of 8 patients in CIPROFLOXACIN group respectively. Although side effects were seen less frequently in CIPROFLOXACIN group, the difference was not. statistically significant. We conclude that use of CIPROFLOXACIN in bismuth s. C., based QUADRUPLE THERAPY for eradication of HELICOBACTER PYLORI is not superior to regimens which contains METRONIDAZOLE.

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References

TRIAL COMPARING METRONIDAZOLE AND FURAZOLIDONE (OMEPRAZOLE, TETRACYCLINE, BISMUTH PLUS METRONIDAZOLE VS FURAZOLIDONE) FOR ERADICATION OF HELICOBACTER PYLORI IN IRANIAN PEPTIC ULCER DISEASE PATIENTS

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APA: Copy

VOSOUGHINIA, H.. (2003). CIPROFLOXACIN VS. METRONIDAZOLE IN QUADRUPLE THERAPY REGIMENS FOR THE TREATMENT OF H .PYLORI INFECTION IN PATIENTS WITH DUODENAL ULCER. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 46(79), 21-26. SID. https://sid.ir/paper/52231/en

Vancouver: Copy

VOSOUGHINIA H.. CIPROFLOXACIN VS. METRONIDAZOLE IN QUADRUPLE THERAPY REGIMENS FOR THE TREATMENT OF H .PYLORI INFECTION IN PATIENTS WITH DUODENAL ULCER. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2003;46(79):21-26. Available from: https://sid.ir/paper/52231/en

IEEE: Copy

H. VOSOUGHINIA, “CIPROFLOXACIN VS. METRONIDAZOLE IN QUADRUPLE THERAPY REGIMENS FOR THE TREATMENT OF H .PYLORI INFECTION IN PATIENTS WITH DUODENAL ULCER,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 46, no. 79, pp. 21–26, 2003, [Online]. Available: https://sid.ir/paper/52231/en

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