DENOUEMENT CONTINUED FROM PAGE 32 YOUR DIAGNOSIS PLEASE?

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PANAHI M.

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Journal Paper

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Journal: Medical Journal of Mashhad University of Medical Sciences Year:2005 | Volume:48 | Issue:88 Page(s): 221-223

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Title

DENOUEMENT CONTINUED FROM PAGE 32 YOUR DIAGNOSIS PLEASE?

Author(s)

PANAHI M. | Issue Writer Certificate

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Abstract

Peripheral blood smear and CBC revealed leukocytosis (15, 500), an absolute lymphocytosis (80%) and an increase in the number of atypical lymphocytes. The most striking finding of peripheral film was Downey cells, a large mononuclear cell with eccenteric nucleus. Atypical lymocytes represented 12% of WBCs. These finding strongly suggest Infectious Mononuleosis, but it should be kept in mind that atypical lymphocytes may also occur in other diseases, like CMV infection, toxoplasmosis, Bacterial endocarditis, streptococcal infections and hypersensitivity states.Both relative and absolute neutropenia often develop early in the course of Inf Mononucleosis. Toxic granules and Dohle bodies may also be present.So the definitive diagnosis of Inf Mononucleosis is established by EBV-Specific serology. Recovery of the virus does not distinguish between current and past infections. In those cases where Inf Mononucleosis produces clinically apparent disease, aditional tests such as Hetrophil antibodies titer and WBC count and differential, find a place in diagnosis. So hetrophil antibody test (Paul-Bunnell) was done and it was positive.Recent advances in immunology have permitted the application of latex agglutination, RIA and Elisa assay to detection of the hetrophil response.Aplastic anemia is the most serious hematologic complication of Inf Mononucleosis. Less serious but more common than paneytophenia is the occurrence of hemolytic anemia affecting 0.5% to 3% of the patients with Infect Mononucleosis. Almost all episodes of hemolysis resolve spontaneously.Thrombocytopenia and platelet function abnormalities have also been described in Inf mononucleosis. Abnormal platelet aggregation and release of PLT factors have been reported. Dermatological manifestation occurs between 5%-10%, administration of antibiotic agents and appearance of a Maculopapular rask is a common complication of antibiotic therapy in IM, especially who receive ampicillin or penicillin. Exudative pharyngeal infection may be the result of streptococal infection. Neurologic complication occurring with EBV infection include: encephalitis, Meningitis, optic neuritis Guillian Barre' synd, SSPE, depression and psychosis. Depression occurs quite frequently in some patients objects appear distorted and change in size that is called "Alice in wonder -land syndrome".This patient received corticosteroid and after that acute symptom relieved. Routine administration of steroids in all cases to engender unnecessary risk. Additional therapies include INF-2, Metronidzole, Tinidazole, Acyclovir and There agents decrease anaerobic flora in the throat. Clinical controlled trials have not demonstrated any benefit in Acyclovir therapy.

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APA: Copy

PANAHI, M.. (2005). DENOUEMENT CONTINUED FROM PAGE 32 YOUR DIAGNOSIS PLEASE?. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 48(88), 221-223. SID. https://sid.ir/paper/52269/en

Vancouver: Copy

PANAHI M.. DENOUEMENT CONTINUED FROM PAGE 32 YOUR DIAGNOSIS PLEASE?. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2005;48(88):221-223. Available from: https://sid.ir/paper/52269/en

IEEE: Copy

M. PANAHI, “DENOUEMENT CONTINUED FROM PAGE 32 YOUR DIAGNOSIS PLEASE?,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 48, no. 88, pp. 221–223, 2005, [Online]. Available: https://sid.ir/paper/52269/en

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