AGNOR QUANTITATIVE AND QUALITATIVE EVALUATION IN BENIGN AND MALIGNANT MELANOCYTIC LESIONS

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GHIASI MOGHADAM T.; FATHI M.; GHANADAN A.R.

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Journal: Iranian Journal of Basic Medical Sciences Year:2003 | Volume:5 | Issue:4 (16) Page(s): 206-211

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Information Journal Paper

Title

AGNOR QUANTITATIVE AND QUALITATIVE EVALUATION IN BENIGN AND MALIGNANT MELANOCYTIC LESIONS

Author(s)

GHIASI MOGHADAM T. | FATHI M. | GHANADAN A.R. | Issue Writer Certificate

Keywords

AGNORQ4

MELANOCYTICLESIONSQ3

MELANOMAQ4

Abstract

Nucleolar Organizer Regions (NORS) are loops of ribosomal (rDNA) in the nucleolus and are associated with acidic proteins. They are seen in routinely processed paraffin sections by using a one – step colloidal silver (Ag) staining method; they appear as black dots termed" AGNORs ". It has been suggested that the number of AGNOR per cell can differentiate between benign and malignant rnelanocytic lesions of skin. In our study the method of staining nucleolar organizer regions (NORs) with colloid silver nitrate was applied to the paraffin sections of one junctional nevus, 14 compoundnevi, 15 intradermal nevi, 3 spitz nevi, 3 lentigo malignant MELANOMAs, 13malignant MELANOMAs and 3 secondary MELANOMAs. There was a significant different between the pooled silver, NOR (AGNOR) numbers of the 33 benign lesions (mean ±SD= 1.733± 1.567) and the 19 MELANOMAs (mean ± SD =8.027± 1.658) by t-test analysis (P<0.001). The difference was striking enough to be recognized on causal microscopic examination, suggesting that AGNOR staining may be a usual technique to help melanocytic nevi from malignant MELANOMAs.

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APA: Copy

GHIASI MOGHADAM, T., FATHI, M., & GHANADAN, A.R.. (2003). AGNOR QUANTITATIVE AND QUALITATIVE EVALUATION IN BENIGN AND MALIGNANT MELANOCYTIC LESIONS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 5(4 (16)), 206-211. SID. https://sid.ir/paper/52360/en

Vancouver: Copy

GHIASI MOGHADAM T., FATHI M., GHANADAN A.R.. AGNOR QUANTITATIVE AND QUALITATIVE EVALUATION IN BENIGN AND MALIGNANT MELANOCYTIC LESIONS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2003;5(4 (16)):206-211. Available from: https://sid.ir/paper/52360/en

IEEE: Copy

T. GHIASI MOGHADAM, M. FATHI, and A.R. GHANADAN, “AGNOR QUANTITATIVE AND QUALITATIVE EVALUATION IN BENIGN AND MALIGNANT MELANOCYTIC LESIONS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 5, no. 4 (16), pp. 206–211, 2003, [Online]. Available: https://sid.ir/paper/52360/en

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