EFFECT OF SALVIA LERIIFOLIA LEAVES EXTRACT ON LIVER TRANSAMINASES IN MICE.

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HOSSEINZADEH H.; EGHBAL A.

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Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2002 | Volume:4 | Issue:4 (12) Page(s): 207-214

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Information Journal Paper

Title

EFFECT OF SALVIA LERIIFOLIA LEAVES EXTRACT ON LIVER TRANSAMINASES IN MICE.

Author(s)

HOSSEINZADEH H. | EGHBAL A. | Issue Writer Certificate

Keywords

SALVIA LERIIFOLIAQ4

SERUMTRANSAMINASESQ2

HEPATOTOXICITYQ4

ACETAMINOPHENQ3

MICEQ4

Abstract

In this study, the effect of SALVIA LERIIFOLIA leaves extract on liver transaminases was evaluated in MICE. Dry powdered leaves were macerated in 80%ethanol for 2 days. The maximum tolerated dose of extract was 1500 mg/kg via intraperitoneal injection. The level of blood enzyme SGOT and SGPT of MICE was measured as an index of HEPATOTOXICITY. The high doses of the extracts (200, 900, 1200 and 1500 mg/kg) induced HEPATOTOXICITY but the low dose of the plant extracts (50 and 100 mg/kg)did not induced any significant effect on the isoenzymes. The lower doses did not show any hepatoprotective effect against carbon tetrachloride (25 µl/kg) and ACETAMINOPHEN (500 mg/kg) HEPATOTOXICITY.The present results indicated that the maceratede thanolic extract of S. leriifolia leaves extract did not have hepatoprotective effects and in high doses itself induced heptotoxicity.

Cites

EVALUATION OF TERATOGENICITY OF SALVIA LERIIFOLIA BENTH. IN MICE

References

اثرات عصاره های آبی و الکلی دانه و برگ گیاه نوروزک (Salvia leriifolia) بر مدت زمان زنده ماندن موش های در معرض هیپوکسی

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APA: Copy

HOSSEINZADEH, H., & EGHBAL, A.. (2002). EFFECT OF SALVIA LERIIFOLIA LEAVES EXTRACT ON LIVER TRANSAMINASES IN MICE.. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 4(4 (12)), 207-214. SID. https://sid.ir/paper/52367/en

Vancouver: Copy

HOSSEINZADEH H., EGHBAL A.. EFFECT OF SALVIA LERIIFOLIA LEAVES EXTRACT ON LIVER TRANSAMINASES IN MICE.. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2002;4(4 (12)):207-214. Available from: https://sid.ir/paper/52367/en

IEEE: Copy

H. HOSSEINZADEH, and A. EGHBAL, “EFFECT OF SALVIA LERIIFOLIA LEAVES EXTRACT ON LIVER TRANSAMINASES IN MICE.,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 4, no. 4 (12), pp. 207–214, 2002, [Online]. Available: https://sid.ir/paper/52367/en

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