PROTECTIVE EFFECT OF CROCIN AGAINST CISPLATIN-INDUCED ACUTE RENAL DAMAGE IN RAT

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NAGHIZADEH B.; BOROUSHAKI M.T.; MOFIDPOUR H.

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Journal: Iranian Journal of Basic Medical Sciences Year:2007 | Volume:9 | Issue:4 (32) Page(s): 281-286

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Title

PROTECTIVE EFFECT OF CROCIN AGAINST CISPLATIN-INDUCED ACUTE RENAL DAMAGE IN RAT

Author(s)

NAGHIZADEH B. | BOROUSHAKI M.T. | MOFIDPOUR H. | Issue Writer Certificate

Keywords

KIDNEY FAILUREQ1

CISPLATINQ3

CROCINQ2

Abstract

ObjectiveCisplatin is the most effective chemotherapeutic agent against solid tumors including ovarian, head and neck carcinomas. The major side effect of CISPLATIN is nephrotoxicity. Reactive oxygen species (ROS) and oxidative damage are the most important factors in CISPLATIN-induced acute renal failure. The main site of CISPLATIN toxicity is the straight portion of proximal tubules (S3 segment). CROCIN, a carotenoid of saffron, is responsible for the red color of saffron and has many pharmacological effects. The main purpose of this study is to investigate the protective effect of CROCIN against CISPLATIN-induced acute renal damage in rat.Materials and MethodsIn this study, male Wistar rats were randomly divided into 5 groups (6 each) and put in metabolic cages. Group one received normal saline (2 ml/day) for four days as control group. Group 2 received a single dose of CISPLATIN (5 mg/kg) for one day. Groups 3 to 5 received (100, 200 and 400 mg/kg) CROCIN respectively, for 4 consecutive days followed by a single dose of CISPLATIN (5 mg/kg) only on first day. All injections were carried out intraperitoneally. On the fifth day, all animals were killed; blood samples were taken out by cardiac puncture for measuring the level of urea and creatinine. The right kidney was removed and fixed in 10% neutral buffered formalin for histopathological examination. On the fourth day, 24-hour urine samples were collected for measuring glucose and protein concentration.ResultsAccording to the results, urea, creatinine, glucose and protein concentrations in CISPLATIN-treated group were significantly higher than control and CROCIN-treated groups. Blood urea and creatinine and urinary glucose and protein concentrations in CROCIN-treated groups were significantly lower than CISPLATIN-treated group. Histopathological studies showed massive damage in the S3 segment of proximal tubules in CISPLATIN-treated group. No damage was observed in CROCIN-treated groups.ConclusionThe results of the present study suggest that CROCIN has protective effect against CISPLATIN-induced acute renal damage, by reducing the level of blood urea and creatinine and urinary glucose and protein.

Cites

اثر ترکیبی تمرینات منظم دویدن و صمغ گیاهی بر متغیرهای عملکردی و اسکلروز گلومرولی کلیه در پرفشار خونی مزمن

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APA: Copy

NAGHIZADEH, B., BOROUSHAKI, M.T., & MOFIDPOUR, H.. (2007). PROTECTIVE EFFECT OF CROCIN AGAINST CISPLATIN-INDUCED ACUTE RENAL DAMAGE IN RAT. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 9(4 (32)), 281-286. SID. https://sid.ir/paper/52388/en

Vancouver: Copy

NAGHIZADEH B., BOROUSHAKI M.T., MOFIDPOUR H.. PROTECTIVE EFFECT OF CROCIN AGAINST CISPLATIN-INDUCED ACUTE RENAL DAMAGE IN RAT. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2007;9(4 (32)):281-286. Available from: https://sid.ir/paper/52388/en

IEEE: Copy

B. NAGHIZADEH, M.T. BOROUSHAKI, and H. MOFIDPOUR, “PROTECTIVE EFFECT OF CROCIN AGAINST CISPLATIN-INDUCED ACUTE RENAL DAMAGE IN RAT,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 9, no. 4 (32), pp. 281–286, 2007, [Online]. Available: https://sid.ir/paper/52388/en

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