HEPATOPROTECTIVE EFFECTS OF FUMARIA PARVIJLORA LAM. AGAINST CCL4 TOXICITY ON FRESHLY ISOLATED RAT HEPATOCYTES

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JAMSHIDZADEH A.; NIKNAHAD H.; FEREIDOUNI F.

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Journal: Iranian Journal of Basic Medical Sciences Year:2005 | Volume:8 | Issue:2 (26) Page(s): 86-92

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Title

HEPATOPROTECTIVE EFFECTS OF FUMARIA PARVIJLORA LAM. AGAINST CCL4 TOXICITY ON FRESHLY ISOLATED RAT HEPATOCYTES

Author(s)

JAMSHIDZADEH A. | NIKNAHAD H. | FEREIDOUNI F. | Issue Writer Certificate

Keywords

FUMARIA PARVIFLORAQ2

LIVERQ2

CCI4Q4

IN VITROQ3

Abstract

Objective: The LIVER is the key organ of the metabolic, secreatory and excretory functions in the body and, accordingly, its disorders are numerous and varied. In folk remedies the plant FUMARIA PARVIFLORA Lam is used for LIVER diseases. In this study, protective effect of hydroalcoholic; extract of FUMARIA PARVIFLORA L was determined on isolated rat hepatocytes to develop new remedies with LIVER protective effects. Material and Methods: After isolating hepatocytes by collagenase, several concentrations of ethanolic extracts were added to the suspension of freshly isolated rat hepatocytes incubated in Krebs-Henscleit buffer under a flow of 95% O2 and 5% CO2, 20-minutes before the addition of 10 mM of CCl4. Then the percentage of cell death was investigated after 0.5, 1, 2, 3 hours by Trypan Blue Exclusion test. Results: The extract with concentrations of 0.7 to 4.2 mg/ml protected the cells against CCl4-induced cytotoxicity, but concentrations of 7 mg/ml and higher increased the CCl4-induced cytotoxicity. Conclusion: The results of the present study support the traditional beliefs on hepatoprotective effects of FUMARIA PARVIFLORA, however; high concentrations were hepatotoxic.

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APA: Copy

JAMSHIDZADEH, A., NIKNAHAD, H., & FEREIDOUNI, F.. (2005). HEPATOPROTECTIVE EFFECTS OF FUMARIA PARVIJLORA LAM. AGAINST CCL4 TOXICITY ON FRESHLY ISOLATED RAT HEPATOCYTES. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 8(2 (26)), 86-92. SID. https://sid.ir/paper/52430/en

Vancouver: Copy

JAMSHIDZADEH A., NIKNAHAD H., FEREIDOUNI F.. HEPATOPROTECTIVE EFFECTS OF FUMARIA PARVIJLORA LAM. AGAINST CCL4 TOXICITY ON FRESHLY ISOLATED RAT HEPATOCYTES. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2005;8(2 (26)):86-92. Available from: https://sid.ir/paper/52430/en

IEEE: Copy

A. JAMSHIDZADEH, H. NIKNAHAD, and F. FEREIDOUNI, “HEPATOPROTECTIVE EFFECTS OF FUMARIA PARVIJLORA LAM. AGAINST CCL4 TOXICITY ON FRESHLY ISOLATED RAT HEPATOCYTES,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 8, no. 2 (26), pp. 86–92, 2005, [Online]. Available: https://sid.ir/paper/52430/en

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