SYNTHESIS OF NOVEL BENZYLIMIDAZOLYLHYDANTOINS AS ANTIEPILOPTICS

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HADIZADEH F.; KARIMI NOGHABI M.

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Journal: Iranian Journal of Basic Medical Sciences Year:2001 | Volume:4 | Issue:3 (11) Page(s): 170-174

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Information Journal Paper

Title

SYNTHESIS OF NOVEL BENZYLIMIDAZOLYLHYDANTOINS AS ANTIEPILOPTICS

Author(s)

HADIZADEH F. | KARIMI NOGHABI M. | Issue Writer Certificate

Keywords

ANTIEPILEPSYQ4

HYDANTOINQ4

BENZYLIMIDAZOLEQ4

Abstract

In order to investigate the effect of replacement of phenyl ring with imidazolyl at active metabolite of antiepileptic drug ethotoin, we decided to synthesize benzylimidazolylhydantoins. First, starting from dihydroxy acetone and benzylamine hydrochloride, 5- hydroxymethyl-1- phenylmethyl-2 (3H) imidazolinethione.[1] was synthesized which was subsequently alkylated by alkyl halides. After oxidation of the resulting 1-benzyl-2- alkylthio 5- hydroxymethylimidazole [2] with MnO2, 1-benzyl -2-alkylthio -5- formylimidazole [3] was obtained. Finally aldehyde [3] was reacted with ammonium carbonate and sodium cyanide accoring to Bucherer reaction to give the title compound, 5- (1-benzyl- 2- alkylthio -5- imidazolyl) imidazoline -2,4- dione [4].

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APA: Copy

HADIZADEH, F., & KARIMI NOGHABI, M.. (2001). SYNTHESIS OF NOVEL BENZYLIMIDAZOLYLHYDANTOINS AS ANTIEPILOPTICS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 4(3 (11)), 170-174. SID. https://sid.ir/paper/52461/en

Vancouver: Copy

HADIZADEH F., KARIMI NOGHABI M.. SYNTHESIS OF NOVEL BENZYLIMIDAZOLYLHYDANTOINS AS ANTIEPILOPTICS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2001;4(3 (11)):170-174. Available from: https://sid.ir/paper/52461/en

IEEE: Copy

F. HADIZADEH, and M. KARIMI NOGHABI, “SYNTHESIS OF NOVEL BENZYLIMIDAZOLYLHYDANTOINS AS ANTIEPILOPTICS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 4, no. 3 (11), pp. 170–174, 2001, [Online]. Available: https://sid.ir/paper/52461/en

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