THE EFFECT OF THYMOQUINONE ON GLOBAL ISCHEMIA-REPERFUSION IN RATS

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PARVARDEH S.; NASIRIASL M.; HOSSEINZADEH H.

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Journal: Iranian Journal of Basic Medical Sciences Year:2004 | Volume:7 | Issue:2 (22) Page(s): 65-70

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Information Journal Paper

Title

THE EFFECT OF THYMOQUINONE ON GLOBAL ISCHEMIA-REPERFUSION IN RATS

Author(s)

PARVARDEH S. | NASIRIASL M. | HOSSEINZADEH H. | Issue Writer Certificate

Keywords

THYMOQUINONEQ3

NIGELLA SATIVAQ2

LIPID PEROXIDATIONQ2

MALONDIALDEHYDEQ4

THIOBARBITURIC ACIDQ4

Abstract

THYMOQUINONE is the major active constituent of the volatile oil of NIGELLA SATIVA seeds. It has been previously reported that THYMOQUINONE prevents oxidative injury in various hepatotoxicity models and may prevent membrane LIPID PEROXIDATION. In order to clarify the effect of THYMOQUINONE on LIPID PEROXIDATION in CNS, we induced cerebral ischemic/reperfusion injury in rats using four-vessel occlusion (4-VO) method and consequently determined MALONDIALDEHYDE (MDA) levels in hippocampus based on its reaction with THIOBARBITURIC ACID (TBA). THYMOQUINONE (2.5-10 mg/kg), phenytoin (50 mg/kg) and control (l0 ml/kg) were administered immediately after reperfusion. The MDA level was higher in control group (normal saline) following ischemic-reperfusion than THYMOQUINONE treated groups. The MDA levels recovered significantly upon phenytoin and THYMOQUINONE (5, 10 mg/kg) therapy following ischemic/reperfusion. These results suggest that THYMOQUINONE may exhibit neuroprotective effect through an inhibitory activity against LIPID PEROXIDATION during cerebral ischemia in rats.

Cites

PHARMACOLOGICAL EVALUATION OF THE CA-CHANNELS ROLE IN THE INHIBITORY EFFECTS OF THYMOQUINONE ON THE CONTRACTILE RESPONSES OF RAT ISOLATED VAS DEFERENS

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APA: Copy

PARVARDEH, S., NASIRIASL, M., & HOSSEINZADEH, H.. (2004). THE EFFECT OF THYMOQUINONE ON GLOBAL ISCHEMIA-REPERFUSION IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 7(2 (22)), 65-70. SID. https://sid.ir/paper/52514/en

Vancouver: Copy

PARVARDEH S., NASIRIASL M., HOSSEINZADEH H.. THE EFFECT OF THYMOQUINONE ON GLOBAL ISCHEMIA-REPERFUSION IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2004;7(2 (22)):65-70. Available from: https://sid.ir/paper/52514/en

IEEE: Copy

S. PARVARDEH, M. NASIRIASL, and H. HOSSEINZADEH, “THE EFFECT OF THYMOQUINONE ON GLOBAL ISCHEMIA-REPERFUSION IN RATS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 7, no. 2 (22), pp. 65–70, 2004, [Online]. Available: https://sid.ir/paper/52514/en

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