EFFECT OF GRANULATION LIQUID ON GRANULE AND MATRIX ROPERTIES OF HYDROXYPROPYLMETHYL CELLULOSE AND PROPRANOLOL HCL

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SADEGHI FATEMEH; BAKHSHIZADEH M.

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Journal: Iranian Journal of Basic Medical Sciences Year:2001 | Volume:3 | Issue:3-4 (8) Page(s): 138-146

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Title

EFFECT OF GRANULATION LIQUID ON GRANULE AND MATRIX ROPERTIES OF HYDROXYPROPYLMETHYL CELLULOSE AND PROPRANOLOL HCL

Author(s)

SADEGHI FATEMEH | BAKHSHIZADEH M. | Issue Writer Certificate

Keywords

HYDROXYPROPYLMETHYL CELLULOSEQ4

SUSTAINED RELEASEQ3

WET GRANULATIONQ4

HYDROPHILIC MATRICESQ4

Abstract

Cellulose ethers especially HYDROXYPROPYLMETHYL CELLULOSE (HPMC) are the polymers of choice as the rate controlling carriers for preparation of HYDROPHILIC MATRICES. To improve powder flow of HPMC which cause problems during tablet manufacturing on high-speed rotary tablet presses a grnulation step may be necessary. The objective of this study was to evaluate the effect of binding solvents on granule and tablet properties and also drug release from HP MC matrices. The model drug used for this study was propranolol HCl. The drug/polymer mixtures were wet granulated with different combinations of water and ethanol. Granule properties such as particle size, flow rate, tap and bulk density was determined. Then matrices were prepared from granules and their crushing strength, friability, drug release rate and mechanism were investigated. DV spectroscopy was used in drug release studies. The results showed that WET GRANULATION process improved powder flow of polymer and drug mixtures and this was attributed to the increase in size of particles after granulation. The mean diameter of granules decreased with increasing ethanol content of binder solvent and correspondingly their flow rates decreased. Overall the hardness of the tablets decreased and their friabilities increased after granulation processes but they were in reasonable range. The hardness of the tablets was independent of composition of binding solvent used in granulation process. It was also observed that binder solvent composition had no effect on drug release rate and mechanism. In conclusion WET GRANULATION process is a voluble method of granulating high molecular weight HPMC in order to improve its flow rate and water is recommended as the cheapest, the safest and the most abundant solvent in WET GRANULATION of HPMC matrices.

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APA: Copy

SADEGHI, FATEMEH, & BAKHSHIZADEH, M.. (2001). EFFECT OF GRANULATION LIQUID ON GRANULE AND MATRIX ROPERTIES OF HYDROXYPROPYLMETHYL CELLULOSE AND PROPRANOLOL HCL. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 3(3-4 (8)), 138-146. SID. https://sid.ir/paper/52524/en

Vancouver: Copy

SADEGHI FATEMEH, BAKHSHIZADEH M.. EFFECT OF GRANULATION LIQUID ON GRANULE AND MATRIX ROPERTIES OF HYDROXYPROPYLMETHYL CELLULOSE AND PROPRANOLOL HCL. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2001;3(3-4 (8)):138-146. Available from: https://sid.ir/paper/52524/en

IEEE: Copy

FATEMEH SADEGHI, and M. BAKHSHIZADEH, “EFFECT OF GRANULATION LIQUID ON GRANULE AND MATRIX ROPERTIES OF HYDROXYPROPYLMETHYL CELLULOSE AND PROPRANOLOL HCL,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 3, no. 3-4 (8), pp. 138–146, 2001, [Online]. Available: https://sid.ir/paper/52524/en

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