ANTIBIOTIC-LOADED PLGA NANOPARTICLES AGAINST PSEUDOMONAS AERUGINOSA

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ABDI ALI AHYA; SABAEIFARD PARASTOO; SOUDI MOHAMMAD REZA

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Journal: Iranian Journal of Infectious Diseases and Tropical Medicine Year:2016 | Volume:21 | Issue:74 Page(s): 1-6

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Information Journal Paper

Title

ANTIBIOTIC-LOADED PLGA NANOPARTICLES AGAINST PSEUDOMONAS AERUGINOSA

Author(s)

ABDI ALI AHYA | SABAEIFARD PARASTOO | SOUDI MOHAMMAD REZA | Issue Writer Certificate

Keywords

POLYMERIC NANOPARTICLESQ1

PLGAQ1

AMIKACINQ3

BIOFILMQ2

PSEUDOMONAS AERUGINOSAQ2

Abstract

Background and objective: PSEUDOMONAS AERUGINOSA BIOFILM is of interest due to its involvement cystic fibrosis and prosthesis-related infections. Unique BIOFILM structure, the vast application of antibiotics and accordingly antibiotic resistance, increase the need for new drug delivery methods to enhance drug efficiency. Nanocarriers are one of the new choices. The aim of the presented study is to evaluate the efficiency of AMIKACIN-loaded PLGA nanoparticles in P. aeruginosa BIOFILM eradication.Materials and methods: Antibacterial (MIC and MBC) and antibiofilm (MBEC) activity of synthesized nanoparticle, by double emulsification method, was assayed against P. aeruginosa PAO1.Results: The synthesized nanoparticles contain an appropriate amount of antibiotic (≈26 mg AMIKACIN/mg/ nanoparticle) and have a suitable size (≈440 nm) for inhalation and injection. The particles are sustainable, have a good antibiotic release kinetic for antibacterial applications. Furthurmore, the antibiotic loaded in the particles also keep their antibacterial activity.Conclusion: AMIKACIN is known to possess nephrotoxic and ototoxic properties and therefore loading it in a polymeric cover, makes the nanoparticles suitable candidate antibacterial and antibiofilm applications with fewer side effects.

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APA: Copy

ABDI ALI, AHYA, SABAEIFARD, PARASTOO, & SOUDI, MOHAMMAD REZA. (2016). ANTIBIOTIC-LOADED PLGA NANOPARTICLES AGAINST PSEUDOMONAS AERUGINOSA. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, 21(74), 1-6. SID. https://sid.ir/paper/52865/en

Vancouver: Copy

ABDI ALI AHYA, SABAEIFARD PARASTOO, SOUDI MOHAMMAD REZA. ANTIBIOTIC-LOADED PLGA NANOPARTICLES AGAINST PSEUDOMONAS AERUGINOSA. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE[Internet]. 2016;21(74):1-6. Available from: https://sid.ir/paper/52865/en

IEEE: Copy

AHYA ABDI ALI, PARASTOO SABAEIFARD, and MOHAMMAD REZA SOUDI, “ANTIBIOTIC-LOADED PLGA NANOPARTICLES AGAINST PSEUDOMONAS AERUGINOSA,” IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, vol. 21, no. 74, pp. 1–6, 2016, [Online]. Available: https://sid.ir/paper/52865/en

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