WILL IGFBP-1 RESPONSE TO ENDURANCE EXERCISE BE ABOLISHED IN EFFECT OF HYPERGLYCEMIA AND HYPERINSULINEMIA ?

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MOHEBI HAMID

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Journal: Year:2003 | Volume:- | Issue:17 Page(s): 63-80

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Title

WILL IGFBP-1 RESPONSE TO ENDURANCE EXERCISE BE ABOLISHED IN EFFECT OF HYPERGLYCEMIA AND HYPERINSULINEMIA ?

Author(s)

MOHEBI HAMID | Issue Writer Certificate

Keywords

SPORT

GLUCOSE

INSULIN

IGFBP-1

IGFS

Abstract

Prolonged exercise increases plasma INSULIN growth factor binding protein-1 (IGFBP-1) in response to a decline in plasma INSULIN and GLUCOSE. In a previous study, it was speculated that factors of exercise per se might also regulate IGFBP-1 secretion, as values increased despite euglycaemia under carbohydrate feeding. Therefore, to determine the effect of exercise per se on circulation of IGFBP-1, the present study undertook prolonged exercise during hyperglycemic and hyperinsulinemic clamps. Eight trained male cyclists cycled at 70% VO2max for 120 min on two separate occasions under either an intravenous GLUCOSE clamp (G) at 10 mmol/l, or a GLUCOSE (10 mmol/l) and INSULIN clamp (GI) at 40 mU/sqm/min. Fasting venous blood samples taken at rest both before and after clamp and also during exercise were analyzed for IGFI, IGFBP-1 and IGFBP-3 using specific radio immunoassay. Plasma GLUCOSE was maintained at 10 mmol/l in both trials. Plasma INSULIN averaged 32±7.3 and 102±16.6 mU/ml during exercise in G and GI trials respectively. Plasma IGFBP-1 was not changed 30 min after either clamps, but significantly decreased after 60 min and 120 min exercise in both trials (P<0.001). It would appear from these findings that the high levels of exogenous GLUCOSE and INSULIN completely suppress IGFBP-1 secretion during the exercise and/or enhance IGFBP-1 clearance from the circulation. We conclude that INSULIN is the primary regulator of IGFBP-1 and that there is no effect of exercise on IGFBP-1 regulation.

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APA: Copy

MOHEBI, HAMID. (2003). WILL IGFBP-1 RESPONSE TO ENDURANCE EXERCISE BE ABOLISHED IN EFFECT OF HYPERGLYCEMIA AND HYPERINSULINEMIA ?. HARAKAT, -(17), 63-80. SID. https://sid.ir/paper/528681/en

Vancouver: Copy

MOHEBI HAMID. WILL IGFBP-1 RESPONSE TO ENDURANCE EXERCISE BE ABOLISHED IN EFFECT OF HYPERGLYCEMIA AND HYPERINSULINEMIA ?. HARAKAT[Internet]. 2003;-(17):63-80. Available from: https://sid.ir/paper/528681/en

IEEE: Copy

HAMID MOHEBI, “WILL IGFBP-1 RESPONSE TO ENDURANCE EXERCISE BE ABOLISHED IN EFFECT OF HYPERGLYCEMIA AND HYPERINSULINEMIA ?,” HARAKAT, vol. -, no. 17, pp. 63–80, 2003, [Online]. Available: https://sid.ir/paper/528681/en

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