CROSS-LINKED POLY (VINYL ALCOHOL) HYDROGEL: STUDY OF SWELLING AND DRUG RELEASE BEHAVIOUR

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VARSHOUSAZ J.; KOOPAIE N.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Polymer Journal Year:2002 | Volume:11 | Issue:2 Page(s): 123-131

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Information Journal Paper

Title

CROSS-LINKED POLY (VINYL ALCOHOL) HYDROGEL: STUDY OF SWELLING AND DRUG RELEASE BEHAVIOUR

Author(s)

VARSHOUSAZ J. | KOOPAIE N. | Issue Writer Certificate

Keywords

HYDROGEL

MATRIX

POLY (VINYL ALCOHOL)

DIFFUSION

SWELLING

Abstract

Cross-linked poly (vinyl alcohol) (PVA) is a prolonged-release micromatrix, a hydrophilic polymer and a potentially interesting HYDROGEL, which is useful for drug delivery applications. As a part of drug development procedure the aim of this study was to investigate the effect of structural changes on drug release (theophylline) from this polymeric network. The studied parameters included: cross-linking agent (glutaraldehyde) concentration, PVA content of the films, theophylline percentage and their overall effect on SWELLING of the HYDROGELs, drug loading efficiency, DIFFUSION and release characteristics of theophylline from PVA films. Changes in glutaraldehyde percentage (or cross-linking density) affected the SWELLING of the films. However, increasing PVA percentage caused more SWELLING, Drug loading efficiency was higher in gels with higher glutaraldehyde, PVA and theophylline percentages. Increasing contents of PVA and theophylline promoted the DIFFUSION coefficient and drug release rate but glutaraldehyde had a reverse effect. The pH did not affect the SWELLING and DIFFUSION coefficient. Water transport and drug release mechanism predominantly followed a Fickian model. It may be concluded that by changing the PVA structural parameters, a rate-controlled drug release is obtained.

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APA: Copy

VARSHOUSAZ, J., & KOOPAIE, N.. (2002). CROSS-LINKED POLY (VINYL ALCOHOL) HYDROGEL: STUDY OF SWELLING AND DRUG RELEASE BEHAVIOUR . IRANIAN POLYMER JOURNAL (ENGLISH), 11(2), 123-131. SID. https://sid.ir/paper/528743/en

Vancouver: Copy

VARSHOUSAZ J., KOOPAIE N.. CROSS-LINKED POLY (VINYL ALCOHOL) HYDROGEL: STUDY OF SWELLING AND DRUG RELEASE BEHAVIOUR . IRANIAN POLYMER JOURNAL (ENGLISH)[Internet]. 2002;11(2):123-131. Available from: https://sid.ir/paper/528743/en

IEEE: Copy

J. VARSHOUSAZ, and N. KOOPAIE, “CROSS-LINKED POLY (VINYL ALCOHOL) HYDROGEL: STUDY OF SWELLING AND DRUG RELEASE BEHAVIOUR ,” IRANIAN POLYMER JOURNAL (ENGLISH), vol. 11, no. 2, pp. 123–131, 2002, [Online]. Available: https://sid.ir/paper/528743/en

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